Jarineshin Hashem, Saljoughi Fateme, Estabraghnia Babaki Hamideh, Hassaniazad Mehdi, Kheirandish Masoumeh, Ghanbarnejad Amin, Sohrabipour Shahla
Critical Care and Pain Management Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Student Research Committee, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Med J Islam Repub Iran. 2021 Jan 13;35:7. doi: 10.47176/mjiri.35.7. eCollection 2021.
There is sparse information to describe the clinical features and outcomes of patients infected with coronavirus disease 2019 (COVID-19). In a single-center retrospective observational study, 50 patients infected with COVID-19 were studied. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Outcomes of critically ill patients and noncritically ill patients were compared. The mean age of the patients was 48.8 years, with male predominance. Dry cough, fever, and dyspnea were the most complaining symptoms on admission. Chronic medical illnesses before admission were present in 56% of the patients. The most common laboratory abnormalities were lymphopenia, neutrophilia, thrombocytopenia, increased aspartate aminotransferase, high serum creatinine level, elevated lactate dehydrogenase, and increasing ESR and CRP levels. Bilateral mixed ground-glass opacity and consolidation were observed in chest CT scan of most patients. Some patients required supplemental oxygen and some needed invasive mechanical ventilation. Blood oxygen saturation was different between survivors and nonsurvivors. 10% of patients died, of whom 60% were men. 40% of dead cases had chronic medical illnesses; 60% underwent invasive mechanical ventilation. Among the patients diagnosed with COVID-19 infection, the frequent clinical presentation was with a wide range of signs and symptoms. The laboratory changes suggest that COVID-19 infection may be related to cellular immune deficiency, myocardial, hepatic, and kidney injury. Additional research is needed to elucidate COVID-19 pathogenesis.
关于2019冠状病毒病（COVID-19）感染患者的临床特征和预后，目前可用信息稀少。在一项单中心回顾性观察研究中，对50例COVID-19感染患者进行了研究。收集并分析了流行病学、人口统计学、临床、实验室、影像学和治疗数据。比较了重症患者和非重症患者的预后。患者的平均年龄为48.8岁，以男性为主。干咳、发热和呼吸困难是入院时最常见的主诉症状。56%的患者入院前患有慢性疾病。最常见的实验室异常包括淋巴细胞减少、中性粒细胞增多、血小板减少、天门冬氨酸氨基转移酶升高、血清肌酐水平升高、乳酸脱氢酶升高以及血沉和C反应蛋白水平升高。大多数患者的胸部CT扫描显示双侧混合性磨玻璃影和实变。一些患者需要补充氧气，一些患者需要有创机械通气。幸存者和非幸存者的血氧饱和度有所不同。10%的患者死亡，其中60%为男性。40%的死亡病例患有慢性疾病；60%接受了有创机械通气。在确诊为COVID-19感染的患者中，常见的临床表现具有广泛的体征和症状。实验室检查结果提示，COVID-19感染可能与细胞免疫缺陷、心肌、肝脏和肾脏损伤有关。需要进一步研究以阐明COVID-19的发病机制。
