Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Student Research Committee, Ilam University of Medical Sciences, Iran.
Ethiop J Health Sci. 2022 May;32(3):485-496. doi: 10.4314/ejhs.v32i3.3.
COVID-19 is the last global threat which WHO confirmed it as a pandemic on March 11, 2020. In the Middle East, Iran was the first country where the SARS-Cov-2 was detected. The epidemiological and economic challenges of Iran make this country a particularly relevant subject of study. In the current study, we aimed to evaluate the clinical, radiological and laboratory findings in hospitalized COVID-19 confirmed cases in Ilam province, western of Iran.
Overall, 2204 hospitalized RT-PCR confirmed patients with COVID-19 were considered in this study. Electronic medical records, including clinical symptoms, radiological images, laboratory findings, and the comorbidities of patients with COVID-19 were collected and analyzed. In addition, the medication regimens used in these patients were evaluated. The patients were classified in discharged and died groups according to their outcomes. Then, clinical, radiological and laboratory findings as well as treatment regimens and underlying diseases were compared in these two groups.
Among the patients, 1209 (54.85%) were male and 995 (45.14%) were female. Pneumonia, dyspnea and cough, were the most common clinical data in both discharged and died groups. Among the comorbidities, COPD, and cancer were significantly more common in the dead patients than in the living. The results of laboratory tests showed that blood creatinine, BUN, ESR, Na+, WBC, and neutrophil count have increased in deceased group compared to the survivors. However, the lymphocyte count decreased in deceased patients. The evaluation of radiographs demonstrated that there were significant correlations between bilateral pneumonia, ground glass opacity, bilateral patchy shadowing, and pleural effusion with death.
The current investigation indicated the special profile of COVID-19 in west of Iran. Discharged and dead patients with COVID-19 had distinct clinical, radiological and laboratory features, which were separated by principal component analysis. Identifying these characteristics of the disease would translate into the implementation of practical measures to improve results.
COVID-19 是世界卫生组织（WHO）于 2020 年 3 月 11 日确认的最后一次全球威胁。在中东，伊朗是第一个检测到 SARS-CoV-2 的国家。伊朗面临着流行病学和经济方面的挑战，使其成为一个特别值得研究的对象。在本研究中，我们旨在评估伊朗西部伊拉姆省住院的 COVID-19 确诊病例的临床、放射学和实验室检查结果。
本研究共纳入 2204 例住院的 RT-PCR 确诊 COVID-19 患者。收集并分析了患者的电子病历，包括临床症状、影像学图像、实验室检查结果和 COVID-19 患者的合并症。此外，还评估了这些患者的用药方案。根据患者的结局，将其分为出院组和死亡组。然后，比较了这两组的临床、放射学和实验室检查结果以及治疗方案和基础疾病。
在患者中，1209 例（54.85%）为男性，995 例（45.14%）为女性。肺炎、呼吸困难和咳嗽是出院组和死亡组最常见的临床数据。在合并症中，COPD 和癌症在死亡患者中比在存活患者中更为常见。实验室检查结果表明，死亡组的血肌酐、BUN、ESR、Na+、白细胞和中性粒细胞计数较存活组升高，而淋巴细胞计数下降。胸片评估显示，双侧肺炎、磨玻璃影、双侧斑片状阴影和胸腔积液与死亡有显著相关性。
本研究表明伊朗西部 COVID-19 的特殊表现。COVID-19 出院和死亡患者具有明显不同的临床、放射学和实验室特征，通过主成分分析可以将其区分开来。识别这些疾病的特征将转化为实施切实可行的措施来改善结果。
