Schroeder Kristen, Jonas Kristina
Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Front Mol Biosci. 2021 Apr 30;8:682967. doi: 10.3389/fmolb.2021.682967. eCollection 2021.
The asymmetric life cycle of has provided a model in which to study how protein quality control (PQC) networks interface with cell cycle and developmental processes, and how the functions of these systems change during exposure to stress. As in most bacteria, the PQC network of contains highly conserved ATP-dependent chaperones and proteases as well as more specialized holdases. During growth in optimal conditions, these systems support a regulated circuit of protein synthesis and degradation that drives cell differentiation and cell cycle progression. When stress conditions threaten the proteome, most components of the proteostasis network are upregulated and switch to survival functions that prevent, revert, and remove protein damage, while simultaneously pausing the cell cycle in order to regain protein homeostasis. The specialized physiology of influences how it copes with proteotoxic stress, such as in the global management of damaged proteins during recovery as well as in cell type-specific stress responses. Our mini-review highlights the discoveries that have been made in how utilizes its PQC network for regulating its life cycle under optimal and proteotoxic stress conditions, and discusses open research questions in this model.
[细菌名称]的不对称生命周期提供了一个模型，用于研究蛋白质质量控制（PQC）网络如何与细胞周期和发育过程相互作用，以及这些系统的功能在应激暴露期间如何变化。与大多数细菌一样，[细菌名称]的PQC网络包含高度保守的ATP依赖性伴侣蛋白和蛋白酶以及更特殊的分子伴侣。在最佳条件下生长时，这些系统支持蛋白质合成和降解的调节回路，驱动细胞分化和细胞周期进程。当应激条件威胁蛋白质组时，[细菌名称]蛋白质稳态网络的大多数成分会上调，并切换到生存功能，以预防、逆转和消除蛋白质损伤，同时暂停细胞周期以恢复蛋白质稳态。[细菌名称]的特殊生理学影响其应对蛋白质毒性应激的方式，例如在恢复过程中受损蛋白质的整体管理以及细胞类型特异性应激反应中。我们的小型综述重点介绍了关于[细菌名称]如何利用其PQC网络在最佳和蛋白质毒性应激条件下调节其生命周期的发现，并讨论了该模型中尚未解决的研究问题。
