Ponomareva Olga Y, Ressler Kerry J
Neuropsychiatry Translational Research Fellowship Program, Boston VA Healthcare System, Boston, MA, USA.
McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Neurobiol Stress. 2021 Apr 23;14:100330. doi: 10.1016/j.ynstr.2021.100330. eCollection 2021 May.
Post-traumatic stress disorder (PTSD) is a devastating illness with treatment that is effective in only approximately half of the population. This limited rate of response highlights the necessity for research into underlying individual biological mechanisms that mediate development and progression of this disease, allowing for identification of patient-specific treatments. PTSD has clear sex differences in both risk and symptom patterns. Thus, one approach is to characterize trauma-related changes between men and women who exhibit differences in treatment efficacy and response to trauma. Recent technological advances in sequencing have identified several genomic loci and transcriptional changes that are associated with post-trauma symptomatology. However, although the diagnosis of PTSD is more prevalent in women, the genetic factors underlying sex differences remain poorly understood. Here, we review recent work that highlights current understanding and limitations in the field of sex differences in PTSD and related symptomatology.
创伤后应激障碍（PTSD）是一种具有毁灭性的疾病，其治疗仅对大约一半的患者有效。这种有限的有效率凸显了研究介导该疾病发生和发展的个体生物学机制的必要性，以便确定针对特定患者的治疗方法。PTSD在风险和症状模式方面都存在明显的性别差异。因此，一种方法是对在治疗效果和对创伤的反应上存在差异的男性和女性之间与创伤相关的变化进行特征描述。测序技术的最新进展已经确定了几个与创伤后症状学相关的基因组位点和转录变化。然而，尽管PTSD的诊断在女性中更为普遍，但性别差异背后的遗传因素仍知之甚少。在这里，我们回顾了最近的研究工作，这些工作突出了目前对PTSD及相关症状学中性别差异领域的理解和局限性。
