Tan Chengquan, Ji Yongcheng, Zhao Xichen, Xin Zhongquan, Li Jiaying, Huang Shuangbo, Cui Zhiying, Wen Lijun, Liu Caihua, Kim Sung Woo, Deng Jinping, Yin Yulong
Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China.
Guangdong Hinabiotech Co., Ltd., Guangzhou, 510642, China.
Anim Nutr. 2021 Mar;7(1):111-118. doi: 10.1016/j.aninu.2020.10.004. Epub 2020 Dec 28.
Increased metabolic burdens in breeding sows, which are induced by elevated systemic oxidative stress, could increase the need for nucleotides to repair lymphocyte DNA damage; however, de novo synthesis of nucleotides may be insufficient to cover this increased need. This study investigated the effects of dietary nucleotides on milk composition, oxidative stress status, and the reproductive and lactational performance of sows. Forty multiparous sows were assigned to 2 dietary treatments (Control group, and 1 g/kg Nucleotides group) based on a randomized complete block design using their BW at 85 d of gestation as a block. Sows from 2 groups were fed a restricted diet during gestation and ad libitum during lactation. The experiment lasted from 85 d of gestation to 21 d of lactation. The reproductive performance of sows and the growth performance of suckling piglets were measured. Oxidative stress parameters and milk components were also analysed. Data were analyzed using contrasts in the MIXED procedure of SAS. Sows in the Nucleotides group consumed more feed during the first week ( < 0.01) and from 1 to 21 d ( < 0.05) of lactation than those in Control group. Correspondingly, the litter weight gain of piglets showed a tendency to increase from cross-fostering to 9 d ( = 0.09) and from cross-fostering to 20 d ( = 0.10) in the Nucleotides group relative to the Control group. Additionally, the Nucleotides group was higher ( < 0.01) than the Control group in the concentrations of uridine 5'monophosphate, guanosine 5'monophosphate, inosine 5'monophosphate, adenosine 5'monophosphate and total nucleotides in milk. Furthermore, the Nucleotides group was higher ( < 0.01) than the Control group in the serum levels of total antioxidant capacity ( < 0.01) for sows at 109 d of gestation and glutathione peroxidase for weaning piglets, but lower at the levels of thiobarbituric acid-reactive substances ( < 0.05) in serum of weaning piglets. This study indicated that maternal dietary nucleotides could promote piglet growth, probably due to the higher lactational feed intake and higher concentration of nucleotides in the milk of sows, and lower oxidative stress for both sows and piglets.
繁殖母猪体内系统性氧化应激升高所导致的代谢负担增加，可能会增加修复淋巴细胞DNA损伤所需的核苷酸量；然而，核苷酸的从头合成可能不足以满足这一增加的需求。本研究调查了日粮核苷酸对母猪乳汁成分、氧化应激状态以及繁殖和泌乳性能的影响。根据随机完全区组设计，将40头经产母猪按照妊娠85天时的体重作为区组，分为2种日粮处理组（对照组和1 g/kg核苷酸组）。两组母猪在妊娠期采用限饲，泌乳期采用自由采食。试验从妊娠85天持续至泌乳21天。测定了母猪的繁殖性能和哺乳仔猪的生长性能。还分析了氧化应激参数和乳汁成分。数据采用SAS的MIXED过程中的对比分析。核苷酸组母猪在泌乳第1周（P<0.01）和第1至21天（P<0.05）的采食量高于对照组。相应地，与对照组相比，核苷酸组仔猪的窝重从寄养至9天（P=0.09）和寄养至20天（P=0.10）有增加的趋势。此外，核苷酸组母猪乳汁中5'-单磷酸尿苷、5'-单磷酸鸟苷、5'-单磷酸肌苷、5'-单磷酸腺苷和总核苷酸的浓度高于对照组（P<0.01）。此外，核苷酸组妊娠109天母猪的血清总抗氧化能力（P<0.01）和断奶仔猪的谷胱甘肽过氧化物酶水平高于对照组，但断奶仔猪血清中硫代巴比妥酸反应性物质水平低于对照组（P<0.05）。本研究表明，母体日粮核苷酸可能通过提高母猪泌乳期采食量、增加乳汁中核苷酸浓度以及降低母猪和仔猪的氧化应激来促进仔猪生长。
