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Complement inhibition in severe COVID-19 - Blocking C5a seems to be key.

作者信息

Lim Endry H T, Vlaar Alexander P J, de-Bruin Sanne, Brouwer Matthijs C, van-de-Beek Diederik

机构信息

Department of Intensive Care Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam UMC, 1100DD Amsterdam, the Netherlands.

Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

出版信息

EClinicalMedicine. 2021 Apr 24;35:100722. doi: 10.1016/j.eclinm.2021.100722. eCollection 2021 May.

DOI:10.1016/j.eclinm.2021.100722
PMID:33997737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8099654/
Abstract
摘要

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本文引用的文献

1
Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study.依库珠单抗作为重症监护病房中成年重症 COVID-19 患者的紧急治疗：一项概念验证研究。
EClinicalMedicine. 2020 Nov;28:100590. doi: 10.1016/j.eclinm.2020.100590. Epub 2020 Nov 5.
2
Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial.抗C5a抗体IFX-1（vilobelimab）治疗与最佳支持治疗对重症COVID-19患者的疗效比较（PANAMO）：一项探索性、开放标签的2期随机对照试验。
Lancet Rheumatol. 2020 Dec;2(12):e764-e773. doi: 10.1016/S2665-9913(20)30341-6. Epub 2020 Sep 28.
3
Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis.补体和组织因子富集的中性粒细胞细胞外陷阱是 COVID-19 免疫血栓形成的关键驱动因素。
J Clin Invest. 2020 Nov 2;130(11):6151-6157. doi: 10.1172/JCI141374.
4
Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis.COVID-19 炎症与 C5a-C5aR1 轴的激活有关。
Nature. 2020 Dec;588(7836):146-150. doi: 10.1038/s41586-020-2600-6. Epub 2020 Jul 29.
5
Controlling the anaphylatoxin C5a in diseases requires a specifically targeted inhibition.控制疾病中的过敏毒素 C5a 需要有针对性的特异性抑制。
Clin Immunol. 2017 Jul;180:25-32. doi: 10.1016/j.clim.2017.03.012. Epub 2017 Mar 30.