Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P.R. China.
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20210462.
Histone deacetylase (HDAC) 10, a class II family, has been implicated in various tumors and non-tumor diseases, which makes the discovery of biological functions and novel inhibitors a fundamental endeavor. In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer, immunoglobulin A nephropathy (IgAN), intracerebral hemorrhage, human immunodeficiency virus (HIV) infection and schizophrenia. To date, relatively few studies have investigated HDAC10-specific inhibitors. Therefore, it is important to study the biological functions of HDAC10 for the future development of specific HDAC10 inhibitors. In this review, we analyzed the biological functions, mechanisms and inhibitors of HDAC10, which makes HDAC10 an appealing therapeutic target.
组蛋白去乙酰化酶 (HDAC) 10 属于 II 类家族，与多种肿瘤和非肿瘤疾病有关，这使得发现其生物学功能和新型抑制剂成为一项基本任务。在癌症中，HDAC10 通过其表观遗传功能或靶向某些关键的分子或信号通路，在调节各种细胞过程中发挥重要作用。它也具有针对肿瘤和非肿瘤疾病的潜在临床应用价值，例如肾细胞癌、前列腺癌、免疫球蛋白 A 肾病 (IgAN)、脑出血、人类免疫缺陷病毒 (HIV) 感染和精神分裂症。迄今为止，研究 HDAC10 特异性抑制剂的相对较少。因此，研究 HDAC10 的生物学功能对于未来开发特异性 HDAC10 抑制剂非常重要。在这篇综述中，我们分析了 HDAC10 的生物学功能、机制和抑制剂，这使得 HDAC10 成为一个有吸引力的治疗靶点。
