Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.
J Med Imaging Radiat Oncol. 2021 Apr;65(2):160-165. doi: 10.1111/1754-9485.13127. Epub 2020 Nov 12.
Recently, standardized uptake value (SUV) has been applied for the evaluation of SPECT-CT. This study was performed to investigate the bone SPECT-CT peak SUV for chronic osteomyelitis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ).
Sixty-five patients with jaw lesions (12 chronic osteomyelitis, 12 osteoradionecrosis and 41 MRONJ) underwent SPECT-CT after injection of technetium-99m hydroxymethylene diphosphonate. The peak SUV was compared for the chronic osteomyelitis with osteoradionecrosis and MRONJ using GI-BONE software. Statistical analyses for the peak SUV were performed by one-way repeated measures analysis of variance with Tukey's HSD test. A P-value lower than 0.05 was considered as statistically significant.
Peak SUV for chronic osteomyelitis (15.6 ± 4.4) was significantly higher than those for osteoradionecrosis (6.7 ± 2.1, P = 0.000) and MRONJ (10.7 ± 6.1, P = 0.019).
The SPECT-CT peak SUV using GI-BONE software can be useful for the evaluation of jaw lesions, such as chronic osteomyelitis, osteoradionecrosis and MRONJ.
最近，标准化摄取值（SUV）已被应用于 SPECT-CT 的评估。本研究旨在探讨颌骨 SPECT-CT 峰值 SUV 用于慢性骨髓炎、放射性骨坏死和药物相关性颌骨坏死（MRONJ）的情况。
65 例颌骨病变患者（12 例慢性骨髓炎、12 例放射性骨坏死和 41 例 MRONJ）在注射锝-99m 羟甲基二膦酸盐后进行 SPECT-CT 检查。使用 GI-BONE 软件比较慢性骨髓炎与放射性骨坏死和 MRONJ 的峰值 SUV。采用单因素重复测量方差分析和 Tukey's HSD 检验进行峰值 SUV 的统计学分析。P 值小于 0.05 被认为具有统计学意义。
慢性骨髓炎的峰值 SUV（15.6±4.4）明显高于放射性骨坏死（6.7±2.1，P=0.000）和 MRONJ（10.7±6.1，P=0.019）。
GI-BONE 软件的 SPECT-CT 峰值 SUV 可用于评估颌骨病变，如慢性骨髓炎、放射性骨坏死和 MRONJ。
