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非药物服务是否能减轻士兵疼痛治疗中的阿片类药物用量?

Do nonpharmacological services offset opioids in pain treatment for soldiers?

机构信息

Institute for Behavioral Health, Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts, USA.

Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center, Aurora, Colorado, USA.

出版信息

Health Serv Res. 2021 Dec;56(6):1222-1232. doi: 10.1111/1475-6773.13664. Epub 2021 May 17.

Abstract

OBJECTIVE

To examine the relationships between nonpharmacological treatment (NPT) utilization and opioid prescriptions and doses and whether these relationships vary according to the type of NPT service received.

DATA SOURCE

Secondary data from the US Military Health System, nationwide.

STUDY DESIGN

Patterns of NPT utilization and opioid prescriptions were analyzed over the 23 months after initial pain treatment (index visit). Regression models were used to examine the relationship between opioid prescription use in a given month and NPT service utilization in the three preceding months, using person fixed effects to control for time-invariant patient characteristics, as well as time fixed effects. Analyses were stratified by whether the patient filled an opioid prescription in the first 30 days post index visit.

DATA EXTRACTION METHODS

Administrative data on health care utilization were extracted from the US Military Health System Data Repository for Army service members who returned from deployments in Afghanistan and Iraq that ended in fiscal years 2008 to 2014 and had at least one outpatient visit with a primary diagnosis of musculoskeletal pain in the subsequent year.

PRINCIPAL FINDINGS

Utilization of any NPT service in the past 3 months was positively associated with filling an opioid prescription in the given month, regardless of whether the patient was initially prescribed opioids (percentage point difference [PP] =2.87, P < 0.01) or not (PP = 0.83, P < 0.01). However, for those not initially prescribed opioids, use of any NPT service in the past 3 months was negatively associated with mean daily opioid dose in the given month (morphine milligram equivalent dose = -0.4017, P < 0.01). For those initially prescribed opioids, NPT was not associated with opioid dose.

CONCLUSIONS

NPT only reduced the prescription opioid daily dose for some patients, whereas the probability of receiving an opioid prescription was positively associated with NPT. Future research should assess whether recent system-level policies and program changes influence referral and opioid prescribing patterns.

摘要

目的

研究非药物治疗(NPT)的应用与阿片类药物处方及剂量之间的关系,并探讨这些关系是否因所接受的 NPT 服务类型而异。

资料来源

美国全国性军事卫生系统的二次数据。

研究设计

在初始疼痛治疗后(索引就诊)的 23 个月内,分析 NPT 利用和阿片类药物处方的模式。使用个体固定效应来控制时间不变的患者特征,以及时间固定效应,回归模型用于检验在给定月份开具阿片类药物处方与前三个月 NPT 服务利用之间的关系。分析按患者在索引就诊后 30 天内是否开具阿片类药物处方进行分层。

资料提取方法

从美国军事卫生系统数据仓库中提取了在阿富汗和伊拉克部署结束的财政年度 2008 年至 2014 年期间返回的陆军军人的医疗保健利用情况的行政数据,且在随后的一年中至少有一次门诊就诊,主要诊断为肌肉骨骼疼痛。

主要发现

过去 3 个月内任何 NPT 服务的利用与当月开具阿片类药物处方呈正相关,无论患者最初是否开具阿片类药物(百分点差异[PP] = 2.87,P < 0.01)或未开具阿片类药物(PP = 0.83,P < 0.01)。然而,对于那些最初未开具阿片类药物的患者,过去 3 个月内任何 NPT 服务的利用与当月平均每日阿片类药物剂量呈负相关(吗啡毫克当量剂量 = -0.4017,P < 0.01)。对于那些最初开具阿片类药物的患者,NPT 与阿片类药物剂量无关。

结论

NPT 仅降低了某些患者的处方阿片类药物日剂量,而开具阿片类药物处方的可能性与 NPT 呈正相关。未来的研究应评估最近的系统层面政策和项目变化是否影响转诊和阿片类药物处方模式。

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