Wang Peilin, Lin Haodong
Department of Orthopaedics, Shanghai General Hospital, Shanghai, 200080, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 May 15;35(5):648-655. doi: 10.7507/1002-1892.202012044.
To review the related studies on the application of nanomaterials in the treatment of osteomyelitis, and to provide new ideas for the research and clinical treatment of osteomyelitis.
The literature about the treatment of osteomyelitis with nanomaterials at home and abroad in recent years was reviewed and analyzed.
At present, surgical treatment and antibiotic application are the main treatment options for osteomyelitis. But there are many defects such as antibiotic resistance, residual bone defect, and low effective concentration of local drugs. The application of nanomaterials can make up for the above defects. In recent years, nanomaterials play an important role in the treatment of osteomyelitis by filling bone defects, establishing local drug delivery system, and self-antibacterial properties.
It will provide a new idea and an important research direction for the treatment of osteomyelitis to fully study the related characteristics of nanomaterials and select beneficial materials to make drug delivery system or substitute drugs.
综述纳米材料在骨髓炎治疗中的应用相关研究，为骨髓炎的研究及临床治疗提供新思路。
回顾分析近年来国内外有关纳米材料治疗骨髓炎的文献。
目前，手术治疗和抗生素应用是骨髓炎的主要治疗手段。但存在抗生素耐药、残留骨缺损、局部药物有效浓度低等诸多缺陷。纳米材料的应用可弥补上述缺陷。近年来，纳米材料通过填充骨缺损、建立局部给药系统及自身抗菌特性在骨髓炎治疗中发挥重要作用。
充分研究纳米材料的相关特性，选择有益材料制作给药系统或替代药物，将为骨髓炎的治疗提供新思路及重要研究方向。
