tRNA 衍生的小 RNA 的作用的新见解。
Novel insights into the roles of tRNA-derived small RNAs.
机构信息
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, NationalCenter of Gerontology, National Health Commission; Institute of Geriatric Medicine, ChineseAcademy of Medical Sciences, Beijing 100730, P. R. China.
出版信息
RNA Biol. 2021 Dec;18(12):2157-2167. doi: 10.1080/15476286.2021.1922009. Epub 2021 May 17.
Abstract
tRNA-derived small RNA (tsRNA) is a novel class of non-coding RNA that is usually produced from tRNA following endonuclease cleavage which occurs under stress conditions. There are two types of tsRNAs: tRNA-derived fragments (tRFs) and stress-induced tRNA halves (tiRNAs), which differ in their cleavage position. Many studies have demonstrated that tsRNAs are involved in various physiological and pathological processes apart from cancer and gene expression. In this review, we briefly described the biogenesis, classification, and characteristics of tsRNAs and summarized the current research progress of tsRNAs in metabolic diseases, senescence, reproduction, stress, and organ injury, and finally put forward some problems to be solved.
摘要
tRNA 衍生的小 RNA（tsRNA）是一类新型的非编码 RNA，通常在应激条件下，经内切酶切割 tRNA 后产生。tsRNA 有两种类型：tRNA 衍生片段（tRFs）和应激诱导的 tRNA 半分子（tiRNAs），它们在切割位置上有所不同。许多研究表明，tsRNA 除了在癌症和基因表达中发挥作用外，还参与了多种生理和病理过程。在这篇综述中，我们简要描述了 tsRNA 的生物发生、分类和特征，并总结了 tsRNA 在代谢疾病、衰老、生殖、应激和器官损伤中的研究进展，最后提出了一些需要解决的问题。
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