Wuxi Medical School, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China.
Wuxi Medical School, Jiangnan University, Wuxi 214122, Jiangsu Province, PR China.
Life Sci. 2021 Aug 1;278:119613. doi: 10.1016/j.lfs.2021.119613. Epub 2021 May 14.
SLC9A1 plays an important role in the growth, differentiation and glycolysis of tumor cells. The present study aimed to elucidate the correlation between SLC9A1 and tumor immune infiltration.
Expression level of SLC9A1 gene in tumors was identified in GEPIA. The correlation between SLC9A1 and survival in various types of cancers was analyzed by the PrognoScan. SLC9A1 immune infiltration levels and clinical correlation analysis was generated via TIMER and TIMER2.0. KEGG enrichment analysis of SLC9A1 expression was evaluated via STRING.
We found that, in cancers such as liver hepatocellular carcinoma (LIHC), the expression of SLC9A1 was significantly higher in tumor tissues compared with normal tissues, and was significantly associated with poor prognosis. Further analysis showed that SLC9A1 expression in LIHC was significantly positively correlated with immune cell infiltration, and the correlation was the highest for LIHC among 40 cancers. The expression of SLC9A1 is significantly correlated with the immune marker set of most immune cells in LIHC. Furthermore, we found that the expression level of TGF-β (TGFB1) in Tregs showed the highest correlation with the expression of SLC9A1 in LIHC.
The increased expression of SLC9A1 is positively correlated with the prognosis of cancer and the level of immune infiltration. Therefore, SLC9A1 is an important prognostic factor for immunotherapy against hepatocellular carcinoma.
SLC9A1 在肿瘤细胞的生长、分化和糖酵解中发挥重要作用。本研究旨在阐明 SLC9A1 与肿瘤免疫浸润的相关性。
在 GEPIA 中鉴定肿瘤中 SLC9A1 基因的表达水平。通过 PrognoScan 分析 SLC9A1 与各种癌症生存的相关性。通过 TIMER 和 TIMER2.0 生成 SLC9A1 免疫浸润水平和临床相关性分析。通过 STRING 评估 SLC9A1 表达的 KEGG 富集分析。
我们发现，在肝癌（LIHC）等癌症中，SLC9A1 在肿瘤组织中的表达明显高于正常组织，并且与预后不良显著相关。进一步分析表明，LIHC 中 SLC9A1 的表达与免疫细胞浸润呈显著正相关，在 40 种癌症中，与 LIHC 的相关性最高。SLC9A1 的表达与 LIHC 中大多数免疫细胞的免疫标志物集显著相关。此外，我们发现 Tregs 中 TGF-β（TGFB1）的表达水平与 LIHC 中 SLC9A1 的表达水平呈最高相关性。
SLC9A1 的表达增加与癌症的预后和免疫浸润水平呈正相关。因此，SLC9A1 是针对肝细胞癌免疫治疗的一个重要预后因素。
