HLA - DP抗原与多发性硬化症的易感性有关。

HLA-DP antigens are involved in the susceptibility to multiple sclerosis.

作者信息

Odum N, Hyldig-Nielsen J J, Morling N, Sandberg-Wollheim M, Platz P, Svejgaard A

机构信息

Tissue Typing Laboratory, State University Hospital (Rigshospitalet) Copenhagen, Denmark.

出版信息

Tissue Antigens. 1988 May;31(5):235-7. doi: 10.1111/j.1399-0039.1988.tb02088.x.

DOI:10.1111/j.1399-0039.1988.tb02088.x

PMID:3400089

Abstract

Forty-five unrelated patients with multiple sclerosis (MS) from Sweden and 166 Danish controls were typed for HLA-DP using Primed Lymphocyte Typing. Thirty-nine MS-patients and 63 controls were also DNA-typed with the Restriction Fragment Length Polymorphism (RFLP) technique for HLA-DP and -DR genes. The frequencies of DPw4 were 93.3% in MS patients and 72.3% in controls (relative risk, RR = 5.4, p = 0.0014). The DR2 antigen was present in 75.5% of the patients and in 33.7% of the controls (RR = 6.1, p less than 10(-6)). DPw4 was not associated (i.e., was not in linkage disequilibrium) with DR2 in patients or controls. Thus, in MS the associations with DP and DR are independent of each other. However, the combined presence of DPw4 and DR2 gave a significantly higher risk than each antigen alone, indicating that synergism between DP and DR gene products may play a role in the genetic susceptibility to MS.

摘要

采用预致敏淋巴细胞分型法对来自瑞典的45例无亲缘关系的多发性硬化症（MS）患者及166例丹麦对照者进行了HLA - DP分型。另外，采用限制性片段长度多态性（RFLP）技术对39例MS患者和63例对照者进行了HLA - DP和 - DR基因的DNA分型。MS患者中DPw4的频率为93.3%，对照者中为72.3%（相对危险度，RR = 5.4，p = 0.0014）。DR2抗原在75.5%的患者中存在，在33.7%的对照者中存在（RR = 6.1，p < 10⁻⁶）。在患者或对照者中，DPw4与DR2不相关（即不存在连锁不平衡）。因此，在MS中，与DP和DR的关联是相互独立的。然而，DPw4和DR2同时存在时的风险显著高于单独的每种抗原，这表明DP和DR基因产物之间的协同作用可能在MS的遗传易感性中起作用。