La Mantia L, Illeni M T, Milanese C, Salmaggi A, Eoli M, Pellegris G, Nespolo A
Divisione Neurologica e Laboratorio Analisi dell'Istituto Nazionale Neurologico C. Besta, Milano.
Ital J Neurol Sci. 1991 Feb;12(1):81-6. doi: 10.1007/BF02337618.
We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.
我们分析了104例意大利多发性硬化症患者和905名健康对照者的HLA - A、- C、- B、- DR和 - DQ特异性。多发性硬化症患者中HLA - A23、A26、Cw4、DR3，尤其是DR5抗原的频率显著高于对照组。病程为进展型的患者其B7、B8和DR3抗原频率较高：Cw1和DRw11与鞘内IgG产生程度呈负相关。这些数据证实HLA系统可能影响该疾病的临床表型和免疫反应。
