Department of Ophthalmology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Department of Ophthalmology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210008, Jiangsu Province, China.
BMC Ophthalmol. 2021 May 17;21(1):222. doi: 10.1186/s12886-021-01983-7.
Ocular toxoplasmosis caused by Toxoplasma gondii is an infectious disease which is widely distributed around the world and can present with various clinic manifestations. We are here reporting an unusual case presented with epiretinal membrane (ERM), i.e., macular pucker.
A 16-year old male patient visited our outpatient clinic complaining of decreased vision for about 8 years in his left eye. The best-corrected visual acuity (BCVA) was 20/20 OD and 20/400 OS. There was sensory exotropia in his left eye. No inflammatory cells or flare were found in his anterior chamber or vitreous cavity OU. An ERM involving his left macular area was found on his dilated fundus exam, which was confirmed by Optical Coherence Tomography (OCT). The ERM was found to involve his left macular area with his foveal ellipsoid zone absent. The right eye was found to be within normal limit. After a thorough discussion with the patient and his parents about treatment options and surgical benefits, risks and alternatives, we performed vitrectomy, peeled off the ERM and collected the vitreous sample for parasite testing during the procedure. Patient's blood also was drawn for serological testing. Vitreous sample analysis and serological tests confirmed ocular toxoplasmosis OS as his final diagnosis. Unfortunately, the BCVA of this patient was not improved after the surgery, but the exotropia disappeared.
ERM is an unusual clinical presentation of ocular toxoplasmosis. We may add Toxoplasma gondii infection as a differential diagnosis when encountering ERM cases.
由刚地弓形虫引起的眼弓形体病是一种广泛分布于世界各地的传染病,可表现出各种临床症状。我们在此报告一例不常见的病例,表现为视网膜前膜(ERM),即黄斑皱襞。
一名 16 岁男性患者因左眼视力下降约 8 年来我院门诊就诊。最佳矫正视力(BCVA)右眼为 20/20,左眼为 20/400。左眼有感觉性外斜视。双眼眼前段及玻璃体内均未见炎症细胞或闪辉。散瞳眼底检查发现左眼广泛的 ERM 累及黄斑区,光学相干断层扫描(OCT)证实了这一点。ERM 累及左眼黄斑区,其中心凹椭圆体带缺失。右眼正常。在与患者及其父母充分讨论了治疗方案、手术获益、风险和替代方案后,我们进行了玻璃体切除术,在手术过程中剥离了 ERM 并采集了玻璃体样本进行寄生虫检测。同时也采集了患者的血液进行血清学检测。玻璃体样本分析和血清学检查证实 OS 眼为眼弓形体病。不幸的是,该患者手术后 BCVA 没有提高,但斜视消失了。
ERM 是眼弓形体病的一种不常见临床表现。当遇到 ERM 病例时,我们可以将刚地弓形虫感染作为鉴别诊断之一。