Department for Trauma Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Department for Psychosomatic Medicine, University Medical Center Regensburg, Regensburg, Germany.
Sci Rep. 2021 May 17;11(1):10443. doi: 10.1038/s41598-021-90008-w.
The epidemiology of fracture-related infection (FRI) is unknown, which makes it difficult to estimate future demands and evaluate progress in infection prevention. Therefore, we aimed to determine the nationwide burden's development over the last decade as a function of age group and gender. FRI prevalence as a function of age group and gender was quantified based on annual ICD-10 diagnosis codes from German medical institutions between 2008 through 2018, provided by the Federal Statistical Office of Germany (Destatis). The prevalence of FRI increased by 0.28 from 8.4 cases per 100,000 inhabitants to 10.7 cases per 100,000 inhabitants between 2008 and 2018. The proportion of fractures resulting in FRI increased from 1.05 to 1.23%. Gender distribution was equal. Patients aged 60-69 years and 70-79 years comprised the largest internal proportion with 20.2% and 20.7%, respectively, whereby prevalence increased with age group. A trend towards more diagnoses in older patients was observed with a growth rate of 0.63 for patients older than 90 years. Increasing rates of fracture-related infection especially in older patients indicate an upcoming challenge for stakeholders in health care systems. Newly emerging treatment strategies, prevention methods and interdisciplinary approaches are strongly required.
骨折相关感染（FRI）的流行病学尚不清楚，这使得难以估计未来的需求并评估感染预防的进展。因此，我们旨在确定过去十年中全国负担的发展情况，作为年龄组和性别的函数。根据德国联邦统计局（Destatis）提供的 2008 年至 2018 年德国医疗机构每年 ICD-10 诊断代码，定量评估 FRI 的年龄组和性别分布。2008 年至 2018 年，FRI 的发病率从每 10 万人 8.4 例增加到每 10 万人 10.7 例，增加了 0.28。导致 FRI 的骨折比例从 1.05%增加到 1.23%。性别分布均衡。60-69 岁和 70-79 岁的患者构成最大的内部比例，分别为 20.2%和 20.7%，发病率随年龄组增加而增加。观察到 90 岁以上患者的诊断呈上升趋势，增长率为 0.63。骨折相关感染的发病率呈上升趋势，尤其是在老年患者中，这对医疗保健系统的利益相关者构成了即将到来的挑战。强烈需要新出现的治疗策略、预防方法和跨学科方法。
