Department of Cardiology, Faculty of Medicine, Erzincan Binali Yildirim University, 24000, Erzincan, Turkey.
Int J Cardiovasc Imaging. 2021 Oct;37(10):2881-2889. doi: 10.1007/s10554-021-02259-3. Epub 2021 May 17.
Endothelial dysfunction, oxidative stress, and increased inflammatory activity are the main pathophysiological mechanisms responsible for cardiac remodeling secondary to hypertension. Bilirubin has anti-oxidant, anti-inflammatory, and anti-fibrotic functions. This report's objectives are to determine whether Query identifiers of left atrial (LA) remodeling, total atrial conduction time (TACT) and LA reservoir strain (LARS), are associated with serum total bilirubin levels, and to identify the possible predictors of LA remodeling in newly diagnosed hypertensive subjects. One hundred thirty-four subjects were enrolled in this study. TACT was evaluated by tissue Doppler imaging, and LARS was calculated by speckle-tracking echocardiography. Laboratory parameters were recorded. The subjects were classified into two separate groups according to the median value of TACT and LARS. In patients with supramedian TACT, LA volume index (LAVI) and epicardial adipose tissue (EAT) thickness were higher, while LARS and LVGLS were lower. In subjects with inframedian LARS, TACT was longer, LAVI and EAT thickness were higher, and LVGLS was lower. Patients with supramedian TACT and inframedian LARS were older and had lower total bilirubin. Total bilirubin, EAT thickness, and age were predictors of TACT and LARS. Serum bilirubin levels may have a protective effect on the LA remodeling process in newly diagnosed hypertensive subjects.
内皮功能障碍、氧化应激和炎症活性增加是高血压引起的心脏重构的主要病理生理机制。胆红素具有抗氧化、抗炎和抗纤维化作用。本报告的目的是确定左心房（LA）重构的查询标识符、总心房传导时间（TACT）和 LA 储备应变（LARS）是否与血清总胆红素水平相关，并确定新诊断的高血压患者中 LA 重构的可能预测因子。本研究共纳入 134 例患者。采用组织多普勒成像评估 TACT，应用斑点追踪超声心动图计算 LARS。记录实验室参数。根据 TACT 和 LARS 的中位数将患者分为两组。在 TACT 高于中位数的患者中，左房容积指数（LAVI）和心外膜脂肪组织（EAT）厚度更高，而 LARS 和 LVGLS 更低。在 LARS 低于中位数的患者中，TACT 更长，LAVI 和 EAT 厚度更高，LVGLS 更低。TACT 高于中位数且 LARS 低于中位数的患者年龄更大，总胆红素水平更低。总胆红素、EAT 厚度和年龄是 TACT 和 LARS 的预测因子。血清胆红素水平可能对新诊断的高血压患者的 LA 重构过程具有保护作用。
