Wei Rong-Rui, Ma Qin-Ge
Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, P. R. China.
Z Naturforsch C J Biosci. 2021 May 18;76(11-12):459-465. doi: 10.1515/znc-2021-0001. Print 2021 Nov 25.
Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C (-) and nine known flavonolignan derivatives (-) were isolated from . Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates (-) on RAW264.7 macrophage cells were investigated. Three new compounds (-) demonstrated anti inflammatory activity with IC values ranging from 6.5 ± 0.6 to 14.7 ± 1.6 µM. Furthermore, two compounds ( and ) demonstrated moderate anti inflammatory activity, with IC values ranging from 24.1 ± 1.2 to 62.5 ± 1.9 µM.
例如，黄酮木脂素水飞蓟素和水飞蓟宾具有有趣的生物活性。首次从[具体来源未给出]中分离出三种名为水芹烯酸A - C（-）的新黄酮木脂素和九种已知的黄酮木脂素衍生物（-）。通过综合光谱数据分析和参考文献来鉴定所有化合物。研究了这些分离物（-）对RAW264.7巨噬细胞的抗炎活性。三种新化合物（-）表现出抗炎活性，IC值范围为6.5±0.6至14.7±1.6μM。此外，两种化合物（[具体化合物未明确给出]）表现出中等抗炎活性，IC值范围为24.1±1.2至62.5±1.9μM。
