School of Municipal and Environmental Engineering, Shandong Jianzhu University, Jinan 250100, China.
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, U.S.A.
Biochem J. 2021 May 28;478(10):1847-1852. doi: 10.1042/BCJ20200941.
Plants encode a large number of proteases in activating intracellular signaling through proteolytic cleavages of various protein substrates. One type of the substrates is proligands, including peptide hormones, which are perceived by cell surface-resident receptors. The peptide hormones are usually first synthesized as propeptides, and then cleaved by specific proteases for activation. Accumulating evidence indicates that the protease-mediated cleavage of proligands can be triggered by environmental stresses and subsequently activates plant stress signaling. In this perspective, we highlight several recent publications and provide an update about stress-induced cleavage of propeptides and receptor-associated components by proteases in the activation of cell surface-resident receptor signaling in plants. We also discuss some questions and future challenges in the research of protease functions in plant stress response.
植物通过各种蛋白底物的蛋白水解切割，在激活细胞内信号转导中编码大量的蛋白酶。其中一种底物是前配体，包括被细胞表面驻留受体感知的肽类激素。这些肽类激素通常首先被合成作为前肽，然后被特定的蛋白酶切割激活。越来越多的证据表明，前配体的蛋白酶介导切割可以被环境胁迫触发，随后激活植物应激信号转导。在这个视角下，我们强调了一些最近的出版物，并提供了关于蛋白酶在植物中激活细胞表面驻留受体信号的应激诱导的前肽和受体相关成分切割的最新信息。我们还讨论了蛋白酶在植物应激反应研究中的一些问题和未来挑战。
