Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Psychiatric Research Unit, Psychiatry Region Zealand, Slagelse, Denmark.
JAMA Netw Open. 2021 May 3;4(5):e2110432. doi: 10.1001/jamanetworkopen.2021.10432.
Low socioeconomic status (SES) has been identified as a risk factor for the development of dementia. However, few studies have focused on the association between SES and dementia diagnostic evaluation on a population level.
To investigate whether household income (HHI) is associated with dementia diagnosis and cognitive severity at the time of diagnosis.
DESIGN, SETTING, AND PARTICIPANTS: This population- and register-based cross-sectional study analyzed health, social, and economic data obtained from various Danish national registers. The study population comprised individuals who received a first-time referral for a diagnostic evaluation for dementia to the secondary health care sector of Denmark between January 1, 2017, and December 17, 2018. Dementia-related health data were retrieved from the Danish Quality Database for Dementia. Data analysis was conducted from October 2019 to December 2020.
Annual HHI (used as a proxy for SES) for 2015 and 2016 was obtained from Statistics Denmark and categorized into upper, middle, and lower tertiles within 5-year interval age groups.
Dementia diagnoses (Alzheimer disease, vascular dementia, mixed dementia, dementia with Lewy bodies, Parkinson disease dementia, or other) and cognitive stages at diagnosis (cognitively intact; mild cognitive impairment but not dementia; or mild, moderate, or severe dementia) were retrieved from the database. Univariable and multivariable logistic and linear regressions adjusted for age group, sex, region of residence, household type, period (2017 and 2018), medication type, and medical conditions were analyzed for a possible association between HHI and receipt of dementia diagnosis.
Among the 10 191 individuals (mean [SD] age, 75 [10] years; 5476 women [53.7%]) included in the study, 8844 (86.8%) were diagnosed with dementia. Individuals with HHI in the upper tertile compared with those with lower-tertile HHI were less likely to receive a dementia diagnosis after referral (odds ratio, 0.65; 95% CI, 0.55-0.78) and, if diagnosed with dementia, had less severe cognitive stage (β, -0.16; 95% CI, -0.21 to -0.10). Individuals with middle-tertile HHI did not significantly differ from those with lower-tertile HHI in terms of dementia diagnosis (odds ratio, 0.92; 95% CI, 0.77-1.09) and cognitive stage at diagnosis (β, 0.01; 95% CI, -0.04 to 0.06).
The results of this study revealed a social inequality in dementia diagnostic evaluation: in Denmark, people with higher income seem to receive an earlier diagnosis. Public health strategies should target people with lower SES for earlier dementia detection and intervention.
低社会经济地位(SES)已被确定为痴呆发展的风险因素。然而,很少有研究关注 SES 与人群水平上的痴呆诊断评估之间的关联。
研究家庭收入(HHI)是否与诊断时的痴呆诊断和认知严重程度相关。
设计、地点和参与者:这是一项基于人群和登记的横断面研究,分析了从丹麦各种国家登记处获得的健康、社会和经济数据。研究人群包括 2017 年 1 月 1 日至 2018 年 12 月 17 日期间首次接受丹麦二级保健部门进行痴呆诊断评估的患者。与痴呆相关的健康数据从丹麦痴呆质量数据库中检索。数据分析于 2019 年 10 月至 2020 年 12 月进行。
2015 年和 2016 年的年度 HHI(用作 SES 的代表)由丹麦统计局获得,并按每 5 年间隔年龄组分为上、中、下三分位数。
从数据库中检索痴呆诊断(阿尔茨海默病、血管性痴呆、混合性痴呆、路易体痴呆、帕金森病痴呆或其他)和诊断时的认知阶段(认知正常;轻度认知障碍但无痴呆;或轻度、中度或重度痴呆)。对年龄组、性别、居住地区、家庭类型、时期(2017 年和 2018 年)、药物类型和医疗条件进行单变量和多变量逻辑和线性回归,以分析 HHI 与痴呆诊断之间的可能关联。
在纳入的 10191 名患者(平均[SD]年龄为 75[10]岁;5476 名女性[53.7%])中,8844 名(86.8%)被诊断为痴呆。与低 HHI 组相比,HHI 处于较高三分位数的患者在转诊后接受痴呆诊断的可能性较低(比值比,0.65;95%CI,0.55-0.78),如果被诊断为痴呆,其认知阶段也较轻(β,-0.16;95%CI,-0.21 至-0.10)。HHI 处于中三分位数的患者与 HHI 处于低三分位数的患者相比,在痴呆诊断(比值比,0.92;95%CI,0.77-1.09)和诊断时的认知阶段(β,0.01;95%CI,-0.04 至 0.06)方面没有显著差异。
这项研究的结果揭示了痴呆诊断评估中的社会不平等:在丹麦,高收入人群似乎更早得到诊断。公共卫生策略应针对社会经济地位较低的人群,以更早发现痴呆症并进行干预。