Kim Jong Sei, Cho Yang-Sun
Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Acta Neurochir (Wien). 2021 Aug;163(8):2237-2245. doi: 10.1007/s00701-021-04870-8. Epub 2021 May 18.
A vestibular schwannoma (VS) is a benign nerve sheath tumor derived from the vestibular nerves. The growth rate of VS during long-term follow-up has not yet been fully evaluated. We aimed to investigate the growth rate of newly diagnosed VS and the related predictive factors for tumor growth.
A retrospective review was performed using VS patients who underwent at least two magnetic resonance imaging (MRI) scans before tumor growth was observed. Tumor growth was defined as a size increase of more than 2 mm in the longest diameter of the tumor. To assess the growth rate of VS and related factors, we assessed tumor growth using survival analysis. Survival analysis to assess the growth rate and Cox regression analysis were performed to find related factors.
The study included 118 patients. The mean age of patients was 57.0 ± 12.9 years. During the observation period, the 5-year cumulative growth incidence rate was 41.3% by survival analysis. Extrameatal tumor location and hearing loss were found to be associated with an increased hazard ratio (HR) for tumor growth.
After long-term observation of VS, 41.3% of VS patients presented cumulative growth incidence rate in the first 5 years after diagnosis. Extrameatal tumor location and hearing changes were related to subsequent tumor growth.
前庭神经鞘瘤（VS）是一种起源于前庭神经的良性神经鞘瘤。VS在长期随访中的生长速度尚未得到充分评估。我们旨在研究新诊断VS的生长速度以及肿瘤生长的相关预测因素。
对在观察到肿瘤生长前至少接受过两次磁共振成像（MRI）扫描的VS患者进行回顾性研究。肿瘤生长定义为肿瘤最长径增加超过2毫米。为评估VS的生长速度及相关因素，我们采用生存分析评估肿瘤生长情况。进行生存分析以评估生长速度，并进行Cox回归分析以找出相关因素。
该研究纳入了118例患者。患者的平均年龄为57.0±12.9岁。在观察期内，通过生存分析得出5年累积生长发生率为41.3%。发现肿瘤位于外耳道外以及听力损失与肿瘤生长的风险比（HR）增加相关。
对VS进行长期观察后，41.3%的VS患者在诊断后的前5年出现累积生长发生率。肿瘤位于外耳道外以及听力变化与随后的肿瘤生长有关。
