Department of Geriatrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao, China.
Int J Clin Pract. 2021 Sep;75(9):e14373. doi: 10.1111/ijcp.14373. Epub 2021 May 29.
The resistance exercise effect on the exercise ability in chronic obstructive pulmonary disease (COPD) subjects has drawn considerable attention. However, the relationship between resistance exercise and the exercise ability of COPD subjects is conflicting. This meta-analysis was performed to evaluate this relationship.
A systematic-literature search up to July 2020 was performed in OVID, Embase, Cochrane Library, PubMed, Google scholar for randomised control trials reported relationships between resistance exercise and the exercise ability of COPD subjects, and 13 studies were detected with 1286 subjects at the baseline. Mean differences (MD) with 95% confidence intervals (CIs) were calculated comparing the resistance exercise and the exercise ability of COPD subjects using the continuous method with a random or fixed-effect model.
A significantly higher 6-minutes walk test was observed in subjects performing resistance training (MD, 60.41; 95% CI, 39.97-80.85, P < .001) compared with non-resistance training subjects. However, no significant difference was observed between COPD subjects performing resistance exercise compared with non-resistance training COPD subjects in constant work rate cycle endurance test (MD, 1.59; 95% CI, 0.03-3.15, P = .05), unsupported upper extremity exercise test (MD, 48.77; 95% CI, -1.20 to 98.75, P < .06) and quality of life questionnaires (MD, -0.62; 95% CI, -2.49 to 1.245, P < .51).
The resistance exercise significantly increases the 6-minutes walk test in COPD subjects. However, resistance exercise did not significantly affect the constant work rate cycle endurance test, unsupported upper extremity exercise test and quality of life questionnaires. This relationship forces us to recommend the resistance exercise to improve the 6-minutes walk test as a simple and easy evaluation of functional exercise ability in COPD subjects.
抗阻运动对慢性阻塞性肺疾病（COPD）患者运动能力的影响引起了广泛关注。然而，抗阻运动与 COPD 患者运动能力之间的关系存在争议。本荟萃分析旨在评估这种关系。
系统检索 OVID、Embase、Cochrane 图书馆、PubMed 和 Google Scholar 中截至 2020 年 7 月的随机对照试验，评估抗阻运动与 COPD 患者运动能力之间的关系，共检出 13 项研究，基线时共纳入 1286 例患者。采用随机或固定效应模型的连续方法计算比较 COPD 患者抗阻运动和运动能力的均数差（MD）及其 95%置信区间（CI）。
与非抗阻运动训练组相比，接受抗阻训练的患者 6 分钟步行试验（MD，60.41；95%CI，39.97-80.85，P<.001）显著更高。然而，与非抗阻运动训练的 COPD 患者相比，接受抗阻运动的 COPD 患者在恒功率循环耐力试验（MD，1.59；95%CI，0.03-3.15，P=.05）、非支撑上肢运动试验（MD，48.77；95%CI，-1.20 至 98.75，P<.06）和生活质量问卷（MD，-0.62；95%CI，-2.49 至 1.245，P<.51）方面无显著差异。
抗阻运动显著增加 COPD 患者的 6 分钟步行试验。然而，抗阻运动对恒功率循环耐力试验、非支撑上肢运动试验和生活质量问卷没有显著影响。这种关系促使我们建议进行抗阻运动以提高 6 分钟步行试验，作为 COPD 患者简单易行的功能运动能力评估方法。
