白癜风的遗传模型。
A genetical model for vitiligo.
作者信息
Majumder P P, Das S K, Li C C
机构信息
Department of Biostatistics, University of Pittsburgh, PA 15261.
出版信息
Am J Hum Genet. 1988 Aug;43(2):119-25.
Abstract
A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.
摘要
已发现一种遗传模型能很好地拟合白癜风家族数据。该模型假定，一组四个不连锁的双等位基因座上的隐性等位基因与该疾病的病因有关。在这种多重隐性纯合模型下，对于通过患病亲本确定的正常×患病家庭，预期的分离概率为0.063；估计值为0.53，与预期值无显著差异。对于通过患病后代确定的正常×正常家庭，预期的分离概率为0.037；估计值为0.04。
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