Bhatia P S, Mohan L, Pandey O N, Singh K K, Arora S K, Mukhija R D
Department of Dermatology, B.R.D. Medical College, Gorakhpur, India.
J Dermatol Sci. 1992 Nov;4(3):180-4. doi: 10.1016/0923-1811(92)90017-6.
Four hundred vitiligo patients and 100 non-vitiliginous controls were studied to find out the prevalence of vitiligo in relatives of patients and controls. The difference was found to be statistically highly significant. The data reflected that there is some genetic mechanism involved in the etiology of vitiligo. Respective relatives of all forms of the disease in the vitiligo group showed a clear preponderance compared to controls. There was clustering of affected relatives in vitiligo cases compared to controls. The ratio of affected and unaffected siblings with unaffected parents or one parent affected, the ratio in the children of probands, the ratio in children of affected paternal and maternal grandparents of probands, suggest the polygenic nature of vitiligo.
对400名白癜风患者和100名非白癜风对照者进行了研究，以了解患者亲属和对照者亲属中白癜风的患病率。发现差异具有高度统计学意义。数据表明白癜风的病因涉及一些遗传机制。与对照相比，白癜风组中各种形式疾病的相应亲属明显占优势。与对照相比，白癜风病例中受影响亲属存在聚集现象。父母未受影响或一方受影响的情况下，患病和未患病兄弟姐妹的比例、先证者子女的比例、先证者受影响的祖父母的孙辈子女的比例，均提示白癜风具有多基因性质。
