Khlat M
Faculty of Health Sciences, American University of Beirut.
Am J Hum Genet. 1988 Aug;43(2):188-96.
Effects of consanguineous marriages on couples' fertility and on offspring mortality were investigated in Beirut through a population-based health survey of 2,752 households. A multistage random sampling procedure was used, and information was obtained from all ever-married women in the household about their reproductive performance and genealogical relationship with spouse; demographic and socioeconomic information was also recorded. Twenty-five percent of all marriages were between relatives, and the spouses were first cousins in approximately 57% of all consanguineous marriages. Total pregnancies, live births, and living children were significantly higher among consanguineous couples than among nonconsanguineous ones, as was the proportion dead among children ever born. However, no difference remained in either fertility or mortality, when allowance was made for socioeconomic status, religious affiliation, and marriage duration. The issue of confounding is discussed, and the lack of significant pattern in the final analysis is interpreted as resulting from a long-term practice of consanguineous marriages.
通过对贝鲁特2752户家庭进行的一项基于人群的健康调查,研究了近亲婚姻对夫妇生育能力和子女死亡率的影响。采用了多阶段随机抽样程序,并从家庭中所有已婚妇女那里获取了她们的生育表现以及与配偶的谱系关系信息;还记录了人口统计学和社会经济信息。所有婚姻中有25%是近亲之间的婚姻,在所有近亲婚姻中,约57%的配偶是第一代堂亲。近亲夫妇的总怀孕次数、活产数和存活子女数显著高于非近亲夫妇,已出生子女中的死亡比例也是如此。然而,在考虑社会经济地位、宗教信仰和婚姻持续时间后,生育能力或死亡率方面均不存在差异。讨论了混杂问题,并将最终分析中缺乏显著模式解释为近亲婚姻长期实践的结果。