Torres-Ortuño Ana, Cuesta-Barriuso Rubén, Nieto-Munuera Joaquín, Castiello-Munuera Álvaro, López-Pina José Antonio
Department of Psychiatry and Social Psychology, University of Murcia, Murcia, Spain.
Department of Physiotherapy, University of Murcia, Murcia, Spain.
Patient Prefer Adherence. 2021 May 11;15:967-974. doi: 10.2147/PPA.S310662. eCollection 2021.
The episodic or on-demand administration of clotting factor concentrates in hemophilia patients in the event of hemorrhage is employed to restore hemostasis. Adherence to on-demand treatments needs to be assessed in order to improve patient management, avoiding adverse effects and serious clinical complications.
To validate the Spanish version of the treatment adherence scale in patients with hemophilia, namely, Validated Hemophilia Regimen Treatment Adherence Scale-PRN (VERITAS-PRN).
Eighty-five patients were recruited in three hemophilia patient associations in Spain. The VERITAS-PRN scale was adapted through a back-translation process from English to Spanish. A native Spanish bilingual translator translated the scale from English to Spanish, and subsequently another native English bilingual translator translated the scale from Spanish to English. The scale was applied twice (two months apart) to assess test-retest reliability.
Internal consistency reliability was slightly lower in the VERITAS-PRN in Spanish (0.80) versus the English version (0.85). There were no differences (p > 0.05) between the means of the dimensions or in the total scores between the sample of patients in Spain and the USA. The test-retest reliability coefficient of the scores on the total scale was 0.80 [CI, 0.74-0.86]. The test-retest reliability coefficient was greater than 0.90 in all subscales.
The Spanish version of VERITAS-PRN has high consistency and empirical validity. This scale is useful for assessing the degree of adherence to treatment in adult patients with hemophilia following episodic infusion treatment.
血友病患者在出血时采用凝血因子浓缩物的间歇性或按需给药来恢复止血。需要评估对按需治疗的依从性，以改善患者管理，避免不良反应和严重临床并发症。
验证血友病患者治疗依从性量表的西班牙语版本，即验证的血友病治疗方案治疗依从性量表 - 按需版（VERITAS - PRN）。
在西班牙的三个血友病患者协会招募了85名患者。VERITAS - PRN量表通过从英语到西班牙语的回译过程进行改编。一位西班牙语母语的双语翻译人员将量表从英语翻译成西班牙语，随后另一位英语母语的双语翻译人员将量表从西班牙语翻译成英语。该量表应用两次（间隔两个月）以评估重测信度。
VERITAS - PRN西班牙语版本的内部一致性信度（0.80）略低于英语版本（0.85）。西班牙和美国患者样本在维度均值或总分上没有差异（p>0.05）。总量表得分的重测信度系数为0.80 [CI，0.74 - 0.86]。所有子量表的重测信度系数均大于0.90。
VERITAS - PRN西班牙语版本具有较高的一致性和实证效度。该量表有助于评估成年血友病患者间歇性输注治疗后对治疗的依从程度。
