Zhang Jichen, Lu Jiancan, Zhu Hongling, Zhou Xinglu, Wei Xijuan, Gu Mingjun
The Graduate School, Ningxia Medical University, Yinchuan, Ningxia 750005, China.
Department of Endocrinology, Shanghai Pudong New District Gongli Hospital, Second Military Medical University, Shanghai 200135, China.
Int J Endocrinol. 2021 Apr 28;2021:5566019. doi: 10.1155/2021/5566019. eCollection 2021.
Melatonin is an essential neuroendocrine hormone that participates in the regulation of sleep rhythm and cognitive function. This study aimed to determine serum melatonin levels with mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM).
A total of 247 T2DM patients were recruited in this retrospective study and divided into 75 subjects with MCI and 172 with normal cognition. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCA). Their blood sample was examined for the level of melatonin and other biochemical parameters.
Melatonin concentration was decreased in MCI patients to non-MCI patients ( < 0.001). Melatonin level was negatively correlated with age ( = -0.202; = 0.001), diabetes duration ( = -0.282; < 0.001), serum HbA1c ( = -0.195; = 0.002), hs-CRP ( = -0.324; < 0.001), and TSH ( = -0.184; = 0.004) levels and positively correlated with MoCA score, serum HDL-C ( = 0.145; < 0.001), FT3 ( = 0.241; < 0.001), and FT4 ( = 0.169; = 0.008) levels. The multivariable analysis indicated that fewer years of formal education, longer diabetes duration, higher serum HbA1c, higher serum hs-CRP, and lower serum melatonin are the predisposing factors for MCI.
Lower melatonin level was associated with cognitive impairment in patients with T2DM. Melatonin might serve as a potential protective molecule against cognitive dysfunction in T2DM.
褪黑素是一种重要的神经内分泌激素，参与睡眠节律和认知功能的调节。本研究旨在测定2型糖尿病（T2DM）患者轻度认知障碍（MCI）时的血清褪黑素水平。
本回顾性研究共纳入247例T2DM患者，分为75例MCI患者和172例认知正常者。采用蒙特利尔认知评估量表（MoCA）评估认知功能。检测其血样中的褪黑素水平及其他生化指标。
MCI患者的褪黑素浓度低于非MCI患者（<0.001）。褪黑素水平与年龄（=-0.202；=0.001）、糖尿病病程（=-0.282；<0.001）、血清糖化血红蛋白（HbA1c）（=-0.195；=0.002）、超敏C反应蛋白（hs-CRP）（=-0.324；<0.001）及促甲状腺激素（TSH）（=-0.184；=0.004）水平呈负相关，与MoCA评分、血清高密度脂蛋白胆固醇（HDL-C）（=0.145；<0.001）、游离三碘甲状腺原氨酸（FT3）（=0.241；<0.001）及游离甲状腺素（FT4）（=0.169；=0.008）水平呈正相关。多变量分析表明，受正规教育年限较少、糖尿病病程较长、血清HbA1c较高、血清hs-CRP较高及血清褪黑素较低是MCI的易感因素。
T2DM患者褪黑素水平降低与认知障碍有关。褪黑素可能是T2DM认知功能障碍的潜在保护分子。
