Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Branch of National Clinical Research Center for Metabolic Diseases, Wuhan 430030, China.
Int J Mol Sci. 2022 Jan 3;23(1):504. doi: 10.3390/ijms23010504.
Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer's disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms in many diseases. Circadian rhythm disruption is considered to contribute to both T2DM and AD. Here, we review the relationship among circadian rhythm disruption, T2DM and AD, and suggest that the occurrence and progression of T2DM and AD may in part be associated with circadian disruption. Then, we summarize the promising therapeutic strategies targeting circadian dysfunction for T2DM and AD, including pharmacological treatment such as melatonin, orexin, and circadian molecules, as well as non-pharmacological treatments like light therapy, feeding behavior, and exercise.
2 型糖尿病（T2DM）患者发生阿尔茨海默病（AD）的风险更高。越来越多的证据表明，昼夜节律在许多疾病中的作用日益重要。昼夜节律紊乱被认为与 T2DM 和 AD 都有关系。在这里，我们综述了昼夜节律紊乱、T2DM 和 AD 之间的关系，并提出 T2DM 和 AD 的发生和进展可能部分与昼夜节律紊乱有关。然后，我们总结了针对 T2DM 和 AD 中昼夜节律功能障碍的有前途的治疗策略，包括药理学治疗，如褪黑素、食欲素和昼夜节律分子，以及非药理学治疗，如光照疗法、进食行为和运动。
