Solanki Dhanshree, Kichloo Asim, El-Amir Zain, Dahiya Dushyant Singh, Singh Jagmeet, Wani Farah, Solanki Shantanu
Rutgers University, Piscataway, NJ, USA.
Department of Medicine, Central Michigan University, Saginaw, MI, USA.
Gastroenterology Res. 2021 Apr;14(2):87-95. doi: 10.14740/gr1371. Epub 2021 Apr 21.
There is a paucity of contemporary national estimates for infection (CDI) hospitalizations by age group, sex, and region in the US population. Also, there is lack of contemporary national statistics on CDI hospitalizations with comorbidities.
We analyzed the 2017 National Inpatient Sample (NIS) to determine the population-based rates of CDI hospitalizations, characteristics of hospitalizations with CDI, and the rates of comorbidities associated with CDI hospitalizations.
There were 329,460 CDI-related hospitalizations in 2017 (almost 1% of all hospitalizations). The average age for patients admitted with CDI as a principal or secondary diagnosis was 64.7 years (almost 20 years older when compared with all other hospitalizations). Patients 85 years and older had the highest rate of CDI hospitalizations (716 per 100,000 hospitalizations), and patients less than 18 years of age had the lowest rate (12 per 100,000 hospitalizations). There was a progressive increase in the CDI hospitalization rates with each successive age group. The hospitalization rates were higher in females (114 per 100,000 hospitalizations) than males (88 per 100,000 hospitalizations). The CDI hospitalization rate was highest in the Northeast (109 per 100,000 hospitalizations) and lowest in the West (84 per 100,000 hospitalizations). Fluid and electrolyte disturbance (63.3%) and renal failure (33.4%) were the two most common comorbidities associated with CDI hospitalizations. When CDI is a secondary diagnosis, major loss of function, extreme likelihood of dying, septicemia, and septic shock were more common in comparison to CDI as a principal diagnosis.
CDI hospitalization rates were highest in the elderly over 85 years old and declined with successive decreases in age. Women had higher CDI hospitalization rates than men, and fluid and electrolyte disturbances and renal failure were the most common comorbid conditions. The presence of CDI as a comorbid condition at the time of hospitalization for other principal diagnoses or development of CDI during a hospitalization for other principal diagnoses significantly increases the risk of in-hospital morbidity and mortality.
美国人群中缺乏按年龄组、性别和地区划分的当代艰难梭菌感染（CDI）住院情况的全国性估计数据。此外，也缺乏关于合并症的CDI住院情况的当代全国统计数据。
我们分析了2017年全国住院患者样本（NIS），以确定基于人群的CDI住院率、CDI住院的特征以及与CDI住院相关的合并症发生率。
2017年有329,460例与CDI相关的住院病例（几乎占所有住院病例的1%）。以CDI作为主要或次要诊断入院的患者的平均年龄为64.7岁（与所有其他住院病例相比，几乎大20岁）。85岁及以上的患者CDI住院率最高（每10万例住院病例中有716例），18岁以下的患者住院率最低（每10万例住院病例中有12例）。随着年龄组的依次降低，CDI住院率逐渐上升。女性的住院率（每10万例住院病例中有114例）高于男性（每10万例住院病例中有88例）。CDI住院率在东北部最高（每10万例住院病例中有109例），在西部最低（每10万例住院病例中有84例）。液体和电解质紊乱（63.3%）和肾衰竭（33.4%）是与CDI住院相关的两种最常见的合并症。当CDI为次要诊断时，与CDI作为主要诊断相比，功能严重丧失、死亡可能性极大、败血症和感染性休克更为常见。
85岁以上老年人的CDI住院率最高，并随着年龄的依次降低而下降。女性的CDI住院率高于男性，液体和电解质紊乱以及肾衰竭是最常见的合并症。在因其他主要诊断住院时CDI作为合并症存在，或在因其他主要诊断住院期间发生CDI，会显著增加住院期间发病和死亡的风险。
