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部分性葡萄胎及随后宫腔粘连的管理:一例病例报告及文献综述

Management of Partial Hydatidiform Mole and Subsequent Intrauterine Adhesions: A Case Report and Literature Review.

作者信息

Partosh Dor, Hale Genevieve

机构信息

Nova Southeastern University College of Pharmacy.

出版信息

Innov Pharm. 2020 Oct 28;11(4). doi: 10.24926/iip.v11i4.3445. eCollection 2020.

DOI:10.24926/iip.v11i4.3445
PMID:34007656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8127118/
Abstract

BACKGROUND

Gestational trophoblastic disease (GTD) originates from placental tissue and is among rare human tumors that can be cured even in the presence of widespread metastases. The most common form of GTD is hydatidiform mole (HM), commonly referred to as molar pregnancy. Molar pregnancies have the potential to locally invade the uterus and metastasize and result as a result ofgestational trophoblastic neoplasia. Intrauterine adhesions (IUAs) is a condition where scar tissue develops within the uterine cavity, often following a procedure. Hysteroscopy has been established as the criterion standard for the diagnosis of IUAs, although the optimal adjuvant treatment after surgical intervention remains unclear. ‎.

CASE

A 35-year-old-female underwent suction curettage a week after the detection of a molar pregnancy. Two months later, she suffered from amenorrhea and hormonal therapy was initiated. Saline-infusion sonogram was tried and failed due to cervical stenosis. IUAs leading to scar tissue developed along with uterine polyps. Hysteroscopy successfully lysed IUAs and uterine polyps. The patient conceived two months after stopping hormonal therapy and proceeded to a pregnancy which resulted in a healthy live birth.

CONCLUSION

Although the etiology of the patient's molar pregnancy is still unknown, this report demonstrates the need to utilize hysteroscopy as a primary and early mode of treatment if IUAs are found in patients along with providing adjuvant treatment while utilizing clinical judgement in order to prevent IUAs recurrence. The patient conceived four months after the hysteroscopy resulting in a healthy live birth.

摘要

背景

妊娠滋养细胞疾病(GTD)起源于胎盘组织,是少数即使存在广泛转移也可治愈的人类肿瘤之一。GTD最常见的形式是葡萄胎(HM),通常称为葡萄胎妊娠。葡萄胎妊娠有可能局部侵犯子宫并发生转移,进而导致妊娠滋养细胞肿瘤。宫腔粘连(IUAs)是一种在子宫腔内形成瘢痕组织的病症,通常在手术后出现。宫腔镜检查已被确立为诊断IUAs的标准方法,尽管手术干预后的最佳辅助治疗仍不明确。

病例

一名35岁女性在确诊葡萄胎妊娠一周后接受了刮宫术。两个月后,她出现闭经,开始接受激素治疗。由于宫颈狭窄,尝试进行盐水灌注超声检查但失败了。IUAs导致瘢痕组织形成,并伴有子宫息肉。宫腔镜检查成功地分解了IUAs和子宫息肉。患者在停止激素治疗两个月后怀孕,并顺利产下一名健康活婴。

结论

尽管患者葡萄胎妊娠的病因仍不清楚,但本报告表明,如果在患者中发现IUAs,需要将宫腔镜检查作为主要的早期治疗方式,并在利用临床判断提供辅助治疗以防止IUAs复发。患者在宫腔镜检查四个月后怀孕,并顺利产下一名健康活婴。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccfc/8127118/f81373dbcebe/21550417-11-04-3445-g5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccfc/8127118/8d906dd4a12b/21550417-11-04-3445-g1.jpg
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本文引用的文献

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Supplements to Conventional Treatment After Hysteroscopic Lysis of Intrauterine Adhesions: A Systematic Review.宫腔镜下宫腔粘连松解术后常规治疗的补充:一项系统评价
J Obstet Gynaecol Can. 2020 Aug;42(8):984-1000. doi: 10.1016/j.jogc.2019.09.008. Epub 2019 Dec 24.
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Asherman's syndrome: current perspectives on diagnosis and management.阿谢曼综合征:诊断与治疗的当前观点
Int J Womens Health. 2019 Mar 20;11:191-198. doi: 10.2147/IJWH.S165474. eCollection 2019.
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Manual Compared With Electric Vacuum Aspiration for Treatment of Molar Pregnancy.
手动与电动吸引术治疗葡萄胎的比较。
Obstet Gynecol. 2018 Apr;131(4):652-659. doi: 10.1097/AOG.0000000000002522.
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Assessment of Risk Factors of Intrauterine Adhesions in Patients With Induced Abortion and the Curative Effect of Hysteroscopic Surgery.人工流产患者宫腔粘连危险因素评估及宫腔镜手术疗效观察
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