Bromley L, Hayward A
Middlesex Hospital, London.
Anaesthesia. 1988 May;43(5):356-8. doi: 10.1111/j.1365-2044.1988.tb09011.x.
The absorption of cocaine from the nasal mucosa was measured by serial plasma analysis in patients who received nasal cocaine for routine nasal surgery using the modified Moffett's method. Two groups were compared: one received cocaine alone and one with adrenaline 1:1000 added. Changes in pulse rate and blood pressure were recorded in each group. The group that received intranasal cocaine and adrenaline solution had significantly lower plasma cocaine levels. There was no significant difference in cardiovascular parameters between the two groups.
采用改良的莫菲特法，通过对接受鼻腔可卡因用于常规鼻腔手术的患者进行系列血浆分析，来测定可卡因从鼻黏膜的吸收情况。比较了两组：一组单独使用可卡因，另一组添加1:1000的肾上腺素。记录每组患者的脉搏率和血压变化。接受鼻内可卡因和肾上腺素溶液的组血浆可卡因水平显著较低。两组之间的心血管参数无显著差异。
