Miller S H, Dvorchik B, Davis T S
Plast Reconstr Surg. 1977 Oct;60(4):566-71. doi: 10.1097/00006534-197710000-00011.
After applying 5% or 10% cocaine to the nasal mucosa, blood concentration were measured in 9 patients undergoing rhinoplasty and in 6 unoperated controls. The concentrations in the unoperated persons were lower than in those undergoing rhinoplasty, and lower concentrations were found after 5% solutions in both groups than in those exposed to 10% solutions. There was no correlation between the strength of the solution used and the degree of bleeding or the success of the anesthesia. One patient developed symptoms of toxicity within two minutes of a 5% cocaine application to his nasal mucosa. The cocaine concentrations in his blood were the highest seen in our studies, and we cannot explain this.
在将5%或10%的可卡因应用于鼻黏膜后，对9例接受隆鼻手术的患者和6例未手术的对照者进行了血药浓度测量。未手术者的血药浓度低于接受隆鼻手术者，且两组中使用5%溶液后的血药浓度均低于使用10%溶液后的血药浓度。所用溶液的浓度与出血程度或麻醉效果之间无相关性。1例患者在鼻黏膜应用5%可卡因后两分钟内出现中毒症状。其血液中的可卡因浓度是我们研究中所观察到的最高值，对此我们无法解释。
