手性二烯配体在铱催化不对称芳基硼酸对δ-芳基-α,β,γ,δ-不饱和酮的 1,6-加成反应中的电子调谐。
Electronic tuning of chiral diene ligands in iridium-catalyzed asymmetric 1,6-addition of arylboroxines to δ-aryl-α,β,γ,δ-unsaturated ketones.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
Chem Commun (Camb). 2012 Jan 25;48(7):973-5. doi: 10.1039/c2cc16973h. Epub 2011 Dec 8.
PMID:22159574
Abstract
Asymmetric addition of arylboroxines to δ-aryl-α,β,γ,δ-unsaturated ketones proceeded in the presence of an iridium catalyst coordinated with a chiral diene ligand to give high yields of δ-diaryl ketones with very high enantioselectivity.
摘要
在铱催化剂与手性二烯配体配位的存在下，芳基硼酸对 δ-芳基-α,β,γ,δ-不饱和酮进行不对称加成反应，以高收率得到具有非常高对映选择性的 δ-二芳基酮。
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