Dubey J P
Veterinary Research Laboratory, Montana State University, Bozeman, MT 59717.
Am J Vet Res. 1988 Jun;49(6):905-9.
Fifteen pregnant does were inoculated orally with 10 to 1,000 oocysts of the GT-1 strain of Toxoplasma gondii. Two does were euthanatized on postinoculation days (PID) 10 and 14, and the remaining 13 does aborted or delivered kids transplacentally infected with T gondii on PID 9 to 65. Tissues of all 34 fetuses or kids from the inoculated does were examined for gross and microscopic lesions. Placental necrosis and encephalomyelitis were the most prominent lesions. Toxoplasma gondii invaded the fetal placenta between PID 9 and 11 and invaded fetal tissues 2 to 3 days later. Necrosis attributed to toxoplasmosis, confined to cotyledons, was found in all placentas examined on PID 18. Encephalomyelitis was found in most fetuses or kids between PID 30 and 65. Lesions in fetal tissues were sparse. Because T gondii is rarely found in lesions, histologic examination of the fetal tissues is not likely to help in diagnosing every case of transplacentally induced toxoplasmosis in goats.
15只怀孕母羊经口接种10至1000个刚地弓形虫GT - 1株卵囊。在接种后天数（PID）10和14时对2只母羊实施安乐死，其余13只母羊在PID 9至65时流产或产出经胎盘感染弓形虫的羔羊。对接种母羊所产的全部34只胎儿或羔羊的组织进行大体和显微镜检查。胎盘坏死和脑脊髓炎是最显著的病变。弓形虫在PID 9至11期间侵入胎儿胎盘，并在2至3天后侵入胎儿组织。在PID 18检查的所有胎盘中均发现局限于子叶的由弓形虫病引起的坏死。在PID 30至65期间，大多数胎儿或羔羊出现脑脊髓炎。胎儿组织中的病变较少。由于在病变中很少发现弓形虫，因此对胎儿组织进行组织学检查不太可能有助于诊断每一例经胎盘感染的山羊弓形虫病。
