Dubey J P, Schlafer D H, Urban J F, Lindsay D S
Zoonotic Diseases Laboratory, US Department of Agriculture, Beltsville,MD.
Vet Pathol. 1990 Nov;27(6):411-8. doi: 10.1177/030098589902700605.
Two sows (Nos. 1, 2) were each fed 1,000 Toxoplasma gondii oocysts. Sow No. 1 was fed oocysts at 60 day of gestation and was euthanatized 49 days later. Sow No. 2 was fed oocysts at day 45 of gestation and euthanatized 62 days later. Sow No. 1 had eight dead fetuses of which one was mummified and unsuitable for histologic study. Sow No. 2 had 11 fetuses, of which four fetuses were mummified and unsuitable for histologic examination, two fetuses were dead and five were live. Lesions and Toxoplasma parasites were identified in seven fetuses from sow No. 1 and three fetuses from sow No. 2. No lesions were found in four fetuses from sow No. 2. Toxoplasma gondii was present in trophoblasts and produced areas of necrosis of the chorioallantois with focal placental separation. The predominant lesions were necrotizing placentitis, non-suppurative encephalomyelitis, and myocardial degeneration, necrosis and mineralization. Numerous tachyzoites were seen in trophoblast cells lining areolae in placenta.
两头母猪（编号1、2）分别喂食1000个刚地弓形虫卵囊。母猪1在妊娠60天时喂食卵囊，49天后实施安乐死。母猪2在妊娠45天时喂食卵囊，62天后实施安乐死。母猪1有8个死胎，其中1个为干尸化，不适于组织学研究。母猪2有11个胎儿，其中4个胎儿为干尸化，不适于组织学检查，2个胎儿死亡，5个存活。在母猪1的7个胎儿和母猪2的3个胎儿中发现病变和弓形虫寄生虫。在母猪2的4个胎儿中未发现病变。刚地弓形虫存在于滋养层，导致绒毛膜尿囊出现坏死区域并伴有局灶性胎盘分离。主要病变为坏死性胎盘炎、非化脓性脑脊髓炎以及心肌变性、坏死和矿化。在胎盘乳晕内衬的滋养层细胞中可见大量速殖子。
