Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Clinic of Cardiology, University of Munich, LMU Munich, Munich, Germany.
J Clin Psychol Med Settings. 2022 Mar;29(1):103-112. doi: 10.1007/s10880-021-09787-z. Epub 2021 May 19.
In this prospective observational pilot study patients with the diagnosis of end-stage lung disease and listed for lung transplantation underwent a cognitive function test battery before and after lung transplantation to investigate postoperative cognitive function in three domains (visual and verbal memory, executive functioning, concentration/speed of processing). Additionally we investigated intraoperative risk factors for postoperative cognitive dysfunction. In total, 24 patients were included in this pilot study. The incidence of postoperative cognitive dysfunction was 58.3%. In the cognitive dysfunction group, the domains executive functioning and concentration/attention were significantly impaired whereas memory was not affected. Patients with cognitive impairment had a significantly longer ICU stay. The strongest independent risk factor for the development of cognitive dysfunction was operation time. No influence of cerebral oxygen desaturations on cognitive dysfunction was found. This might have important implications for early psychological rehabilitation strategies in this high-risk patient collective.
在这项前瞻性观察性初步研究中，诊断为终末期肺病且已列入肺移植名单的患者在肺移植前后接受认知功能测试，以研究三个领域（视觉和语言记忆、执行功能、注意力/处理速度）的术后认知功能。此外，我们还研究了术后认知功能障碍的术中危险因素。共有 24 名患者纳入本初步研究。术后认知功能障碍的发生率为 58.3%。在认知功能障碍组中，执行功能和注意力/注意力显著受损，而记忆不受影响。认知障碍患者的 ICU 入住时间明显延长。发生认知功能障碍的独立危险因素是手术时间。未发现脑氧饱和度降低对认知功能障碍的影响。这可能对高危患者群体的早期心理康复策略具有重要意义。
