Davis M J, Denton J, Freemont A J, Holt P J
Rheumatism Research Centre, Manchester Royal Infirmary.
Ann Rheum Dis. 1988 Jul;47(7):559-62. doi: 10.1136/ard.47.7.559.
Serial synovial fluid samples were obtained from patients with rheumatoid arthritis and analysed cytologically. Positive correlations in the serial samples between proportions of polymorphs and ragocytes were found. Based upon the serial synovial fluid cytology, distinct subgroups of rheumatoid joints emerged. Comparison of clinical findings in these subgroups showed that the joints with high ragocyte proportion had a significantly poorer outcome. This study therefore identifies two distinct subgroups of rheumatoid joints on the basis of the nature of the cellular reaction within the joint fluid, which usually holds true during subsequent clinical relapse. Identification of these groups may have prognostic significance.
从类风湿性关节炎患者身上获取系列滑液样本，并进行细胞学分析。发现系列样本中多形核细胞比例与类风湿细胞比例之间存在正相关。基于系列滑液细胞学检查，出现了类风湿关节的不同亚组。对这些亚组的临床发现进行比较表明，类风湿细胞比例高的关节预后明显较差。因此，本研究根据关节液内细胞反应的性质确定了类风湿关节的两个不同亚组，这在随后的临床复发过程中通常也是成立的。识别这些亚组可能具有预后意义。
