Luukkainen R, Alanaatu A, Kaarela K, Huhtala H
Satalinna Hospital, Harjavalta, Finland.
Eur J Med. 1993 May;2(5):284-6.
To evaluate the prognostic value of some synovial fluid variables in patients with rheumatoid arthritis.
Twenty-nine patients with erosive rheumatoid arthritis and hydropsy in a knee joint were followed for 7.5 years in a prospective study. At the start of the study the knee joints were aspirated and 15 synovial fluid variables were analyzed. The patients were divided into two groups according to whether or not there had been progress of radiologically detected destruction in the knee joints during the follow-up.
Of the synovial fluid variables at the start, only C3 (p = 0.030) and acid phosphatase (p = 0.047) differed significantly between the groups, the former being lower and the latter higher in patients with deterioration of knee joints.
These preliminary results may indicate that low synovial fluid C3 and high acid phosphatase predict poor prognosis in a joint affected by rheumatoid arthritis.
评估类风湿关节炎患者某些滑液变量的预后价值。
对29例患有侵蚀性类风湿关节炎且膝关节有水肿的患者进行了为期7.5年的前瞻性研究。在研究开始时，对膝关节进行穿刺，并分析15种滑液变量。根据随访期间膝关节放射学检测到的破坏是否有进展，将患者分为两组。
在研究开始时的滑液变量中，两组之间只有C3（p = 0.030）和酸性磷酸酶（p = 0.047）有显著差异，膝关节恶化的患者中前者较低，后者较高。
这些初步结果可能表明，滑液C3水平低和酸性磷酸酶水平高预示着类风湿关节炎受累关节的预后不良。
