Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Cell Rep. 2021 May 18;35(7):109140. doi: 10.1016/j.celrep.2021.109140.
Bats asymptomatically harbor many viruses that can cause severe human diseases. The Egyptian rousette bat (ERB) is the only known reservoir for Marburgviruses and Sosuga virus, making it an exceptional animal model to study antiviral mechanisms in an asymptomatic host. With this goal in mind, we constructed and annotated the immunoglobulin heavy chain locus, finding an expansion on immunoglobulin variable genes associated with protective human antibodies to different viruses. We also annotated two functional and distinct immunoglobulin epsilon genes and four distinctive functional immunoglobulin gamma genes. We described the Fc receptor repertoire in ERBs, including features that may affect activation potential, and discovered the lack of evolutionary conserved short pentraxins. These findings reinforce the hypothesis that a differential threshold of regulation and/or absence of key immune mediators may promote tolerance and decrease inflammation in ERBs.
蝙蝠无症状携带许多可导致人类严重疾病的病毒。埃及果蝠是马尔堡病毒和 Sosuga 病毒的唯一已知宿主，使其成为研究无症状宿主中抗病毒机制的特殊动物模型。考虑到这一目标，我们构建并注释了免疫球蛋白重链基因座，发现与针对不同病毒的保护性人类抗体相关的免疫球蛋白可变基因发生了扩张。我们还注释了两个功能不同的免疫球蛋白 epsilon 基因和四个独特的功能免疫球蛋白 gamma 基因。我们描述了 ERB 中的 Fc 受体库，包括可能影响激活潜力的特征，并发现缺乏进化保守的短五聚蛋白。这些发现支持了这样一种假设，即调节的差异阈值和/或关键免疫介质的缺失可能促进 ERB 中的耐受和减少炎症。
