Bates Lauren C, Alansare Abdullah, Gibbs Bethany Barone, Hanson Erik D, Stoner Lee
Department of Exercise and Sport, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Department of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, United States.
Front Physiol. 2021 May 3;12:664628. doi: 10.3389/fphys.2021.664628. eCollection 2021.
Prolonged sitting increases cardiovascular disease (CVD) risk, however the physiological mechanisms contributing to CVD from acute sitting exposure are not well-understood. Therefore, this study investigated the heart rate (HR) and variability (HRV) responses to prolonged sitting and after interrupting prolonged sitting (e.g., walking). Electronic databases were searched (inception-August 2020) for studies which exposed adults to prolonged (≥1 h) sitting with and/or without interruptions. Twenty-one articles (27 trials, = ) met inclusion criteria. Prolonged sitting non-significantly increased HR (weighted mean difference (WMD) = 0 bpm, 95% CI: -2, 3) and HRV (standardized mean difference (SMD) = 0.12, 95% CI: -0.08, 0.33) compared to pre-sitting baseline. Interrupting prolonged sitting yielded a non-significant small increase in HR (WMD = 4 bpm, 95% CI: 0, 7) compared to pre-sitting baseline. Sub-group analyses investigating interrupting prolonged sitting revealed small-to-moderate increases in HR in healthy populations (WMD = 6 bpm, 95% CI: 1, 10) and following walking interruptions (WMD = 7 bpm, 95% CI: 3, 11). In conclusion, prolonged sitting does not significantly affect HR or HRV. However, interrupting prolonged sitting yielded a small non-significant increase in HR, potentially indicative of increased metabolic demand. Further research is needed to investigate poor CVD outcomes via autonomic disruption from prolonged sitting.
长时间坐着会增加心血管疾病（CVD）风险，然而，急性久坐导致心血管疾病的生理机制尚不清楚。因此，本研究调查了长时间坐着以及中断长时间坐着（如行走）后的心率（HR）和心率变异性（HRV）反应。检索了电子数据库（起始时间为2020年8月），以查找让成年人长时间（≥1小时）坐着且有和/或没有中断的研究。21篇文章（27项试验，n = ）符合纳入标准。与久坐前基线相比，长时间坐着对HR（加权平均差（WMD）= 0次/分钟，95%置信区间：-2，3）和HRV（标准化平均差（SMD）= 0.12，95%置信区间：-0.08，0.33）的影响不显著。与久坐前基线相比，中断长时间坐着使HR有不显著的小幅增加（WMD = 4次/分钟，95%置信区间：0，7）。调查中断长时间坐着的亚组分析显示，健康人群（WMD = 6次/分钟，95%置信区间：1，10）以及行走中断后（WMD = 7次/分钟，95%置信区间：3，11）的HR有小到中度的增加。总之，长时间坐着对HR或HRV没有显著影响。然而，中断长时间坐着会使HR有小幅不显著的增加，这可能表明代谢需求增加。需要进一步研究以调查长时间坐着通过自主神经紊乱导致不良心血管疾病结局的情况。
