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乳腺癌相关淋巴水肿的特征、预测因素及治疗

Features, Predictors, and Treatment of Breast Cancer-related Lymphedema.

作者信息

Zhang Xiaochen, Oliveri Jill M, Paskett Electra D

机构信息

Division of Population Sciences, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.

出版信息

Curr Breast Cancer Rep. 2020 Dec;12(4):244-254. doi: 10.1007/s12609-020-00381-0. Epub 2020 Sep 9.


DOI:10.1007/s12609-020-00381-0
PMID:34012502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8130904/
Abstract

PURPOSE OF REVIEW: Breast cancer-related lymphedema (BCRL) is a common sequelae among breast cancer survivors. This review provides updated information on recent studies to prevent, diagnose, and actively treat women with BCRL. RECENT FINDINGS: In total, 63 articles were identified from 2015 and 2020 that assessed incidence, risk factors, surveillance, measurement and definition, treatment, and awareness of BCRL. Depending on the approach and timing of assessment, BCRL incidence rates ranged from 9.1% to 39%. Modified radical mastectomy, number of positive lymph nodes, and postoperative complications were linked to BCRL risk, in addition to chemotherapy, radiation, axillary lymph node dissection, advanced cancer stage, and higher body mass index. Early detection showed favorable BCRL outcomes (e.g., severity, symptoms). Exercise, self-management, complete decongestive therapy, bandaging, and surgery had positive effects on BCRL outcomes. SUMMARY: Numerous gaps exist within BCRL literature, such as the value of self-reported surveillance options to identify BCRL early, measurement strategies, and definitions of BCRL. In terms of policies, efforts are needed to educate providers, patients, payers, and legislators about the need for consensus to reduce the burden of BCRL in women being treated for breast cancer.

摘要

综述目的:乳腺癌相关淋巴水肿(BCRL)是乳腺癌幸存者中常见的后遗症。本综述提供了关于近期预防、诊断和积极治疗BCRL女性患者的研究的最新信息。 最新发现:从2015年至2020年共检索到63篇评估BCRL发病率、危险因素、监测、测量与定义、治疗以及认知情况的文章。根据评估方法和时间的不同,BCRL发病率在9.1%至39%之间。除化疗、放疗、腋窝淋巴结清扫、癌症晚期以及较高的体重指数外,改良根治性乳房切除术、阳性淋巴结数量和术后并发症与BCRL风险相关。早期检测显示出较好的BCRL治疗效果(如严重程度、症状)。运动、自我管理、完全减压疗法、包扎和手术对BCRL治疗效果有积极影响。 总结:BCRL文献中存在许多空白,如自我报告监测选项在早期识别BCRL中的价值、测量策略以及BCRL的定义。在政策方面,需要努力教育医疗服务提供者、患者、支付方和立法者,使其认识到达成共识以减轻乳腺癌治疗女性BCRL负担的必要性。

相似文献

[1]
Features, Predictors, and Treatment of Breast Cancer-related Lymphedema.

Curr Breast Cancer Rep. 2020-12

[2]
The incidence and risk factors of related lymphedema for breast cancer survivors post-operation: a 2-year follow-up prospective cohort study.

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[3]
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[4]
Diagnostic Methods, Risk Factors, Prevention, and Management of Breast Cancer-Related Lymphedema: Past, Present, and Future Directions.

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[5]
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Ann Surg Oncol. 2018-7-9

[6]
Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - a long-term observation.

Radiat Oncol. 2019-3-7

[7]
Utilization of bioelectrical impedance analysis for detection of lymphedema in breast Cancer survivors: a prospective cross sectional study.

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[8]
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[9]
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[10]
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引用本文的文献

[1]
High-Frequency Ultrasonography Imaging: Anatomical Measuring Site as Potential Clinical Marker for Early Identification of Breast Cancer-Related Lymphedema.

Biomedicines. 2025-6-6

[2]
Right out of the gate: a mixed method study on the needs and priorities of individuals with or at risk of breast cancer-related lymphedema.

J Cancer Surviv. 2025-5-13

[3]
Sleep quality and risk of obstructive sleep apnea among breast cancer survivors with and without lymphedema.

Sleep Breath. 2024-12-3

[4]
Database study of risk factors for breast cancer-related lymphedema: a statistical analysis of 2359 cases over 10 years.

Surg Today. 2025-5

[5]
Incidence and risk factors for psychological distress in adult female patients with breast cancer: a systematic review and meta-analysis.

Front Psychiatry. 2024-3-13

[6]
ASO Author Reflections: Breast Cancer-Related Lymphedema (BCRL) Surveillance Recommendations with Bioimpedance Spectroscopy.

Ann Surg Oncol. 2023-10

[7]
Breast Cancer-Related Lymphedema (BCRL) and Bioimpedance Spectroscopy: Long-Term Follow-Up, Surveillance Recommendations, and Multidisciplinary Risk Factors.

Ann Surg Oncol. 2023-10

[8]
The effect of combined risk factors on breast cancer-related lymphedema: a study using decision trees.

Breast Cancer. 2023-7

[9]
Symptom Management and Quality of Life of Breast Cancer Patients Using Acupuncture-Related Therapies and Herbal Medicine: A Scoping Review.

Cancers (Basel). 2022-9-26

本文引用的文献

[1]
Optimizing Quality of Life for Patients with Breast Cancer-Related Lymphedema: A Prospective Study Combining DIEP Flap Breast Reconstruction and Lymphedema Surgery.

Plast Reconstr Surg. 2020-4

[2]
The impact of arm lymphedema on healthcare utilization during long-term breast cancer survivorship: a population-based cohort study.

J Cancer Surviv. 2020-3-14

[3]
Responsiveness of the Lymphedema Functioning, Disability, and Health Questionnaire for Upper Limb Lymphedema in Patients with Breast Cancer-Related Lymphedema.

Lymphat Res Biol. 2020-8

[4]
Vascularized Lymph Node Transfer for Patients with Breast Cancer-Related Lymphedema Can Potentially Reduce the Burden of Ongoing Conservative Management.

Lymphat Res Biol. 2020-8

[5]
Effects of Different Bandaging Methods for Treating Patients With Breast Cancer-Related Lymphedema.

Ann Rehabil Med. 2019-12

[6]
Cancer statistics, 2020.

CA Cancer J Clin. 2020-1-8

[7]
Correlation between patency and clinical improvement after lymphaticovenous anastomosis (LVA) in breast cancer-related lymphedema: 12-month follow-up.

Breast Cancer Res Treat. 2019-9-21

[8]
The efficacy of intermittent pneumatic compression as a substitute for manual lymphatic drainage in complete decongestive therapy in the treatment of breast cancer related lymphedema.

Lymphology. 2019

[9]
Effect of yoga exercise on the quality of life and upper extremity volume among women with breast cancer related lymphedema: A pilot study.

Eur J Oncol Nurs. 2019-8-22

[10]
Effect of Home-Based Exercise and Weight Loss Programs on Breast Cancer-Related Lymphedema Outcomes Among Overweight Breast Cancer Survivors: The WISER Survivor Randomized Clinical Trial.

JAMA Oncol. 2019-11-1

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