Samara Evangelia, Stamatiou Konstantinos, Balanika Marina, Tzimas Petros
Department of Anaesthesiology, Onassis Cardiac Surgery Center, Athens, GRC.
Department of Urology, Tzaneio General Hospital of Piraeus, Piraeus, GRC.
Cureus. 2021 Apr 16;13(4):e14521. doi: 10.7759/cureus.14521.
Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials' findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.
舒更葡糖钠通常用作有效的神经肌肉阻滞逆转剂。多项研究表明，它可能会延长凝血酶原时间（PT）和活化部分凝血活酶时间（aPTT）。本综述收集了相关研究，以积累该主题的知识。纳入了9项研究。结果显示，与标准治疗相比，舒更葡糖钠似乎会导致aPTT和PT值短暂升高。然而，临床影响似乎微不足道。尽管如此，试验结果显示出很大的异质性，无法进行荟萃分析。因此，需要更多设计良好的研究才能得出审慎的结论。
