替硝唑与甲硝唑治疗阿米巴肝脓肿的对比研究。

Comparative study of tinidazole and metronidazole in amoebic liver abscess.

作者信息

Khokhani R C, Garud A D, Deodhar K P, Sureka S B, Kulkarni M, Damle V B

出版信息

Curr Med Res Opin. 1977;5(2):161-3. doi: 10.1185/03007997709110158.

Abstract

Twenty proven cases of amoebic liver abscess were treated at random with either tinidazole or metronidazole. The dose of both was 2 g once daily for 2 days. Clinical, radiological, and biochemical follow-up was done for 30 days. Of the 19 patients who completed the trial, complete recovery was observed in all 10 patients given tinidazole and in 5 of 9 patients given metronidazole (p=0.05). Moreover, patients on tinidazole required repeat aspirations less frequently than those on metronidazole. Mild gastrointestinal side-effects occurred in 1 patient on metronidazole. The results suggest that tinidazole is a more efficacious drug than metronidazole, with rapid therapeutic effect.

摘要

20例确诊为阿米巴肝脓肿的患者被随机分为两组，分别接受替硝唑或甲硝唑治疗。两种药物的剂量均为每日1次，每次2g，连用2天。进行了为期30天的临床、影像学和生化随访。在完成试验的19例患者中，接受替硝唑治疗的10例患者全部完全康复，接受甲硝唑治疗的9例患者中有5例完全康复（p=0.05）。此外，接受替硝唑治疗的患者比接受甲硝唑治疗的患者需要重复穿刺的频率更低。1例接受甲硝唑治疗的患者出现了轻度胃肠道副作用。结果表明，替硝唑是一种比甲硝唑更有效的药物，具有快速的治疗效果。