Mathur S N, Itigi A, Rai V
J Int Med Res. 1977;5(6):429-33. doi: 10.1177/030006057300100208.
Tinidazole, a new drug effective against E histolytica, was studied in patients with amoebic liver abscess proved by aspiration of pus. A preliminary open evaluation in fourteen patients provided a cure in all cases. A subsequent comparative study against metronidazole in another twenty-two patients led to a cure in all eleven patients treated with tinidazole and in ten out of eleven patients treated with metronidazole. The response was faster in patients treated with tinidazole. Tinidazole was totally free from side-effects. Tinidazole is a noteworthy addition to anti-amoebic therapy.
替硝唑是一种对溶组织内阿米巴有效的新药，对经脓液抽吸证实为阿米巴肝脓肿的患者进行了研究。对14例患者进行的初步开放性评估显示所有病例均治愈。随后在另外22例患者中与甲硝唑进行的对照研究表明，接受替硝唑治疗的11例患者全部治愈，接受甲硝唑治疗的11例患者中有10例治愈。接受替硝唑治疗的患者反应更快。替硝唑完全没有副作用。替硝唑是抗阿米巴治疗中值得注意的新增药物。
