Harshfield G A, James G D, Schlussel Y, Yee L S, Blank S G, Pickering T G
Cardiovascular Center, New York Hospital-Cornell Medical Center, NY 10021.
Am J Hypertens. 1988 Apr;1(2):168-74. doi: 10.1093/ajh/1.2.168.
This study was undertaken to examine whether blood pressure reactivity measured in the controlled setting of a laboratory could be correlated with blood pressure changes occurring during daily life. The subjects were 164 untreated hypertensives with mild hypertension, all of whom had a 24-hour ambulatory blood pressure recording, during which their activities were unrestricted. One hundred thirteen performed a treadmill exercise test, and 51 performed two active coping tasks (playing a video game or mental arithmetic). Blood pressure was monitored at baseline and during the tasks. Significant correlations were observed between the absolute levels of pressure measured during the laboratory tests and ambulatory monitoring, but these were higher for the active coping tasks (r = 0.53 to 0.75) than the exercise testing (r = 0.26 to 0.46) and were no higher for pressures measured during the tasks than at baseline. Correlations between the changes of blood pressure during the laboratory tasks and the changes occurring during ambulatory monitoring were analyzed in three ways, using simple, multiple, and canonical correlations. In no case were these correlations substantively significant. We conclude that blood pressure reactivity measured in the laboratory may not be readily generalized to changes of pressure in everyday life, as measured by noninvasive ambulatory recorders.
本研究旨在探讨在实验室控制条件下测量的血压反应性是否与日常生活中发生的血压变化相关。研究对象为164名未经治疗的轻度高血压患者，他们均进行了24小时动态血压记录，记录期间其活动不受限制。其中113人进行了跑步机运动试验，51人进行了两项主动应对任务（玩电子游戏或心算）。在基线和任务期间监测血压。在实验室测试和动态监测期间测量的血压绝对值之间观察到显著相关性，但主动应对任务的相关性（r = 0.53至0.75）高于运动测试（r = 0.26至0.46），且任务期间测量的血压并不比基线时更高。使用简单相关、多重相关和典型相关三种方法分析了实验室任务期间血压变化与动态监测期间发生的变化之间的相关性。在任何情况下，这些相关性都没有实质性意义。我们得出结论，通过无创动态记录仪测量，实验室中测量的血压反应性可能无法轻易推广到日常生活中的血压变化。
