Department of Pathology, University of Wisconsin Hospital and Clinics, Madison, WI, USA.
J Int Med Res. 2021 May;49(5):3000605211016748. doi: 10.1177/03000605211016748.
At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available.
Seven patients were analyzed. Platelet counts were available from 57 single-unit transfusions (26 pooled, 31 apheresis). A mixed linear effects model was used and significance was determined using a likelihood ratio test.
When analyzed as the only fixed effect in the model, the use of pooled versus single-donor units and time from transfusion to post-transfusion blood sampling each showed a significant effect on platelet count increments. A mixed linear effect model including both factors showed that transfusing a pooled unit correlated with a 4500±2000/µL greater platelet count increment compared with a single-donor unit, and an increase in time from transfusion to post-transfusion blood sampling lowered the platelet count increment by 300±100/µL per hour.
A small but potentially clinically relevant benefit was observed in transfusing pooled random-donor platelets compared with single-donor units for patients with platelet refractoriness (of any etiology).
在我们的机构中，当人类白细胞抗原 (HLA) 匹配的单位可用时，有时会将血小板反应性（任何病因）的患者从机采血小板切换为混合血小板。
分析了 7 名患者。从 57 次单单位输血（26 次混合，31 次机采）中获得血小板计数。使用混合线性效应模型，并使用似然比检验确定显著性。
当作为模型中的唯一固定效应进行分析时，使用混合血小板与单供者单位以及从输血到输血后采血的时间都对血小板计数增加有显著影响。包括这两个因素的混合线性效应模型表明，与单供者单位相比，输注混合血小板单位与血小板计数增加 4500±2000/µL 相关，从输血到输血后采血的时间增加每小时降低血小板计数增加 300±100/µL。
与输注单供者单位相比，输注混合随机供者血小板对血小板反应性（任何病因）患者有较小但潜在临床相关的益处。
