Sharma Anjali, Arakeri Satish, Kanungo Rahul, Pagi Sajal
Pathology, Shri B M Patil Medical College Hospital & Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Cureus. 2024 Nov 18;16(11):e73907. doi: 10.7759/cureus.73907. eCollection 2024 Nov.
Background The demand for platelet concentrates is increasing for treating patients in clinics such as oncology. Single donor platelets (SDPs) collected through apheresis offer a lower risk of transfusion-related complications. Aim This observational study aims to evaluate hematological changes in donors before and after platelet donation via apheresis, shedding light on donor safety and eligibility criteria. Methods This was a pilot study involving 30 plateletpheresis procedures. Hematological parameters were measured before and after donation, including platelet count and hematocrit. Results All donors were male, with an age range of 18-45 years. Blood group distribution among donors was O+ve (12), A+ve (6), B+ve (5), AB+ve (4), B-ve (1), O-ve (1), and AB-ve (1). The mean fall in platelet count after donation was 50,833/mm. The overall mean fall in hematocrit was 1.16%, with a range of 0.5-2%. For donors with a platelet yield of 3.0x10, the average hematocrit reduction was 1.13%, whereas for donors with a yield of 3.5x10, the reduction was 1.56%. Conclusion Automated cell separators have significantly improved SDP quality and collection efficiency. The correlation between platelet yield and pre-donation platelet count underlines the importance of personalizing collection parameters.
在肿瘤学等临床领域，对血小板浓缩物的需求日益增加。通过单采术采集的单采血小板（SDP）可降低输血相关并发症的风险。目的：本观察性研究旨在评估单采血小板捐献前后献血者的血液学变化，以阐明献血者安全性及资格标准。方法：这是一项涉及30次单采血小板程序的试点研究。在献血前后测量血液学参数，包括血小板计数和血细胞比容。结果：所有献血者均为男性，年龄在18至45岁之间。献血者的血型分布为O+（12人）、A+（6人）、B+（5人）、AB+（4人）、B-（1人）、O-（1人）和AB-（1人）。献血后血小板计数的平均下降为50,833/mm。血细胞比容的总体平均下降为1.16%，范围为0.5%至2%。对于血小板产量为3.0×10的献血者，血细胞比容平均降低1.13%，而对于产量为3.5×10的献血者，降低为1.56%。结论：自动细胞分离器显著提高了SDP的质量和采集效率。血小板产量与献血前血小板计数之间的相关性突显了个性化采集参数的重要性。
