Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nat Immunol. 2010 Dec;11(12):1102-9. doi: 10.1038/ni.1956. Epub 2010 Oct 31.
CD1 activates T cells, but the function and size of the possible human T cell repertoires that recognize each of the CD1 antigen-presenting molecules remain unknown. Using an experimental system that bypasses major histocompatibility complex (MHC) restriction and the requirement for defined antigens, we show that polyclonal T cells responded at higher rates to cells expressing CD1a than to those expressing CD1b, CD1c or CD1d. Unlike the repertoire of invariant natural killer T (NKT) cells, the CD1a-autoreactive repertoire contained diverse T cell antigen receptors (TCRs). Functionally, many CD1a-autoreactive T cells homed to skin, where they produced interleukin 22 (IL-22) in response to CD1a on Langerhans cells. The strong and frequent responses among genetically diverse donors define CD1a-autoreactive cells as a normal part of the human T cell repertoire and CD1a as a target of the T(H)22 subset of helper T cells.
CD1 激活 T 细胞，但识别每种 CD1 抗原呈递分子的人类 T 细胞库的功能和大小仍不清楚。使用一种绕过主要组织相容性复合体 (MHC) 限制和对定义抗原的要求的实验系统，我们表明多克隆 T 细胞对表达 CD1a 的细胞的反应率高于对表达 CD1b、CD1c 或 CD1d 的细胞的反应率。与不变自然杀伤 T (NKT) 细胞的库不同，CD1a 自身反应性库包含多样化的 T 细胞抗原受体 (TCR)。在功能上，许多 CD1a 自身反应性 T 细胞归巢到皮肤，在那里它们响应朗格汉斯细胞上的 CD1a 产生白细胞介素 22 (IL-22)。在遗传上多样化的供体中强烈而频繁的反应将 CD1a 自身反应性细胞定义为人类 T 细胞库的正常组成部分，CD1a 是辅助 T 细胞的 T(H)22 亚群的靶标。
