Department of Radiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Radiology, Yuhuangding Hospital, Qingdao University School of Medicine, Yantai, China.
Adipocyte. 2021 Dec;10(1):285-292. doi: 10.1080/21623945.2021.1924957.
Although much is known about how adipose tissue affects the development of clear cell renal carcinoma (ccRCC), little information is available for the utility of sex-specific abdominal visceral fat composition as a predictor of clear cell renal carcinoma (ccRCC) T stage. We conducted CT-based sex-specific abdominal fat measurements in ccRCC patients to assess whether VFA distribution could predict the ccRCC T stage. In total, 253 patients (182 males and 71 females) from our hospital with pathologically confirmed ccRCC (178 low T-stage and 75 high T-stage) were retrospectively reviewed for the present study. Computed tomography (CT) scans were assessed using ImageJ to differentiate between the visceral and subcutaneous fat areas (VFA and SFA), after which the relative VFA (rVFA) and total fat area (TFA) were computed. The relationships between these fat area-related variables, patient age, sex, and BMI, and ccRCC T stage were then evaluated through univariate and multivariate logistic regression analysis to clarify the association between general or sex-specific abdominal visceral fat and T stage. Following adjustment for age, males with high T stage ccRCC exhibited an increased rVFA as compared to males with low T stage ccRCC, with the same relationship being observed among females. This association between rVFA and high T stage was confirmed through both univariate and multivariate models. As thus, sex-specific visceral fat composition is a reliable independent predictor that can identify both male and female patients with high T stage ccRCC.
虽然人们已经了解了很多关于脂肪组织如何影响透明细胞肾细胞癌（ccRCC）的发展，但对于性别特异性腹部内脏脂肪成分作为预测 ccRCC T 分期的实用性，信息仍然有限。我们对 ccRCC 患者进行了基于 CT 的性别特异性腹部脂肪测量，以评估 VFA 分布是否可以预测 ccRCC T 分期。本研究回顾性分析了我院 253 例经病理证实的 ccRCC 患者（178 例低 T 分期和 75 例高 T 分期），其中男性 182 例，女性 71 例。使用 ImageJ 评估 CT 扫描，以区分内脏脂肪区和皮下脂肪区（VFA 和 SFA），然后计算相对 VFA（rVFA）和总脂肪面积（TFA）。通过单变量和多变量逻辑回归分析评估这些脂肪面积相关变量、患者年龄、性别和 BMI 与 ccRCC T 分期之间的关系，以阐明一般或性别特异性腹部内脏脂肪与 T 分期之间的关系。在调整年龄后，高 T 分期 ccRCC 的男性与低 T 分期 ccRCC 的男性相比，表现出较高的 rVFA，而女性也观察到同样的关系。rVFA 与高 T 分期之间的这种关联在单变量和多变量模型中均得到了证实。因此，性别特异性内脏脂肪成分是一种可靠的独立预测因子，可以识别男性和女性高 T 分期 ccRCC 患者。
