Department for Health Evidence (Mailbox 133), Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.
Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Sci Rep. 2022 Oct 6;12(1):16718. doi: 10.1038/s41598-022-20877-2.
Higher BMI has been associated with lower tumor stage and grade and improved survival in renal cell cancer (RCC). BMI cannot distinguish between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). We examined associations of BMI, VAT, SAT, total adipose tissue (TAT) and relative VAT (rVAT) with tumor stage and grade in RCC patients. In a Dutch multicenter population-based historical cohort study 1039 RCC patients diagnosed between 2008 and 2012 were assessed for VAT and SAT using Computed Tomography images at L3. Sex-stratified multinomial logistic regression analyses were performed (linearly per 10-unit increase) between BMI, VAT, SAT, TAT and relative VAT (rVAT) with tumor stage and Fuhrman grade. Higher VAT, TAT and rVAT were associated with a lower risk of stage IV versus stage I in males (OR 0.93; 95%CI 0.91-0.96, OR 0.95; 95%CI 0.93-0.98, OR 0.97; 95%CI 0.96-0.99, respectively). Females showed similar associations, but only higher VAT was statistically significantly associated with reduced risk of stage IV (OR 0.95 95%CI 0.89-1.00). No associations with grade, SAT or BMI were found. In conclusion, higher VAT and TAT was associated with lower risk of stage IV RCC. This might be due to weight loss or cancer cachexia in stage IV patients.
更高的 BMI 与肾细胞癌 (RCC) 中的肿瘤分期和分级较低以及生存改善相关。BMI 无法区分内脏脂肪组织 (VAT) 和皮下脂肪组织 (SAT)。我们检查了 BMI、VAT、SAT、总脂肪组织 (TAT) 和相对 VAT (rVAT) 与 RCC 患者肿瘤分期和分级的相关性。在一项荷兰多中心基于人群的历史队列研究中，评估了 2008 年至 2012 年间诊断的 1039 名 RCC 患者的 VAT 和 SAT，使用 L3 处的计算机断层扫描图像。对 BMI、VAT、SAT、TAT 和相对 VAT (rVAT) 与肿瘤分期和 Fuhrman 分级进行了性别分层的多项逻辑回归分析 (每增加 10 个单位线性)。较高的 VAT、TAT 和 rVAT 与男性的 IV 期与 I 期相比，风险降低相关 (OR 0.93；95%CI 0.91-0.96，OR 0.95；95%CI 0.93-0.98，OR 0.97；95%CI 0.96-0.99)。女性也表现出类似的相关性，但只有较高的 VAT 与 IV 期风险降低具有统计学意义 (OR 0.95 95%CI 0.89-1.00)。与分级、SAT 或 BMI 均无相关性。总之，较高的 VAT 和 TAT 与 IV 期 RCC 的风险降低相关。这可能是由于 IV 期患者的体重减轻或癌症恶病质所致。
